DegronMD - P08651(NFIC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T307S	TCGA-A6-4105	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7116
p.T307S	DO10670	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7116
p.S310N	TCGA-B5-A1MX	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.818
p.S310N	DO41999	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.818
p.P444H	TCGA-EC-A24G	UCEC	TCGA	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.7694
p.P444H	DO40996	UCEC	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.7694
p.P456S	TCGA-MA-AA41	CESC	TCGA	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.2778
p.P456S	TCGA-MA-AA41	CESC	TCGA	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2222
p.P456S	DO219723	CESC	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.2778
p.P456S	DO219723	CESC	ICGC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2222
p.S276C	TCGA-Q1-A5R3	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.8652
p.S276C	DO49008	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.8652
p.S286L	TCGA-VS-A8EL	CESC	TCGA	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation blocking phosphorylation signal	0.5
p.S286L	DO51624	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation blocking phosphorylation signal	0.5
p.M441I	DO225028	BRCA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.3056
p.M441I	DO229027	LICA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.3056
p.P456L	DO225278	BRCA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.2778
p.P456L	DO225278	BRCA	ICGC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2222
p.Y300N	DO233666	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1667
p.A457S	DO228952	LICA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.25
p.A457S	DO228952	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.A457S	DO229032	LICA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.25
p.A457S	DO229032	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.M317T	DO27947	ORCA	ICGC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.S284L	DO49141	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation blocking phosphorylation signal	0.5556
p.S473L	DO219878	SKCA	ICGC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation blocking phosphorylation signal	0.5278
p.R311H	DO42673	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.3056
p.M432L	SIDM00683	Prostate Carcinoma	GDSC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.0556
p.M432L	ACH-000977	lymph node	CCLE	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.0556
p.M432L	LNCaP-Clone-FGC	prostate	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.0556
p.T301S	SIDM00938	Breast Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.T301S	ACH-000902	Breast Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.K280R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation substituting flanking lysine	0.3333
p.K280R	ACH-000953	Leukemia	CCLE	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation substituting flanking lysine	0.3333
p.K280R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation substituting flanking lysine	0.3333
p.E465K	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.3056
p.S275F	SIDM01052	Ovarian Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.9093
p.S275F	ACH-000308	Ovarian Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.9093
p.S275F	ACH-001414	Bladder Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.9093
p.S275F	EFO-21	ovary	COSMIC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.9093
p.P445L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.6471
p.P445L	SW900	lung	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.6471
p.P447R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.6401
p.P447R	ACH-001127	Leukemia	CCLE	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.6401
p.P447R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.6401
p.T265S	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1389
p.T469M	SIDM00720	Mesothelioma	GDSC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1944
p.R312H	L-1236	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.Q433K	SK-MEL-1	skin	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.0833
p.S297F	EFO-21	ovary	COSMIC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0833
p.K271R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.3056
p.P436L	SW900	lung	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation rewiring degron network	0.1667
p.P438R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation blocking phosphorylation signal	0.6667
p.K302R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6667
p.P467L	SW900	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.P469R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1944
p.S266F	EFO-21	ovary	COSMIC	PSTSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.M454L	LNCaP-Clone-FGC	prostate	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	442:454	Mutation altering degron motif	0.711

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFIC

UniProt ID: P08651

Entrez ID: 4782

Protein name: Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFIC in