DegronMD

Uniprot ID: P08651

Source protein: Nuclear factor 1 C-type

Source gene: NFIC

Class: DEG_ODPH_VHL_1

Location: 442:454

E3 ligase: VHL

DEGRON score: 0.9961

ASA_SCORE: 84.4462

COIL: 0.9606

CONS_SCORE: 0.4052

DSS_SCORE: 0.6383

HELIX: 0.0192

FCONS_SCORE: 1.0236

RIG_SCORE: 0.626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P444H	TCGA-EC-A24G	UCEC	TCGA	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.7694
p.P444H	DO40996	UCEC	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.7694
p.P456S	TCGA-MA-AA41	CESC	TCGA	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.2778
p.P456S	DO219723	CESC	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.2778
p.M441I	DO225028	BRCA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.3056
p.M441I	DO229027	LICA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.3056
p.P456L	DO225278	BRCA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.2778
p.A457S	DO228952	LICA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.25
p.A457S	DO229032	LICA	ICGC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.25
p.M432L	SIDM00683	Prostate Carcinoma	GDSC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.0556
p.M432L	ACH-000977	lymph_node	CCLE	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.0556
p.M432L	LNCaP-Clone-FGC	prostate	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.0556
p.P445L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.6471
p.P445L	SW900	lung	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.6471
p.P447R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.6401
p.P447R	ACH-001127	Leukemia	CCLE	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.6401
p.P447R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.6401
p.Q433K	SK-MEL-1	skin	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.0833
p.P436L	SW900	lung	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.1667
p.P438R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.6667
p.M454L	LNCaP-Clone-FGC	prostate	COSMIC	LAPPPPGLPRLAL	DEG_ODPH_VHL_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08651	Nuclear factor 1 C-type	DEG_ODPH_VHL_1	442:454	LAPPPPGLPRLAL	VHL	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons