DegronMD - Q14157(UBAP2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A642T	TCGA-06-1801	GBM	TCGA	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1667
p.A642T	DO11986	GBM	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1667
p.A642T	ACH-001061	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1667
p.S649F	TCGA-55-8511	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation altering degron motif	0.6871
p.S649F	DO24940	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation altering degron motif	0.6871
p.R134C	TCGA-76-4927	GBM	TCGA	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.0556
p.R134C	DO12556	GBM	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.0556
p.R134C	SIDM01164	Glioma	GDSC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.0556
p.R134C	ACH-000883	Brain Cancer	CCLE	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.0556
p.R134C	SW1783	central nervous system	COSMIC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.0556
p.S984F	TCGA-93-8067	LUAD	TCGA	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.25
p.S984F	DO25113	LUAD	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.25
p.P452L	TCGA-A6-6781	COAD	TCGA	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P452L	DO8447	COAD	ICGC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P452L	SIDM01005	Acute Myeloid Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P452L	ACH-000263	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P452L	ACH-001197	Lymphoma	CCLE	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P452L	ACH-001551	Skin Cancer	CCLE	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P452L	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.T699M	TCGA-AA-3864	COAD	TCGA	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.T699M	TCGA-E6-A2P8	UCEC	TCGA	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.T699M	DO8490	COAD	ICGC	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.T699M	DO40924	UCEC	ICGC	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.L679F	TCGA-AC-A23H	BRCA	TCGA	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.1389
p.L679F	DO2401	BRCA	ICGC	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.1389
p.N975S	TCGA-AP-A0LM	UCEC	TCGA	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.5958
p.N975S	DO43306	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.5958
p.P979S	TCGA-AX-A1CE	UCEC	TCGA	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.6752
p.P979S	DO42280	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.6752
p.R126Q	TCGA-B5-A1N2	UCEC	TCGA	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.2778
p.R126Q	DO41602	UCEC	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.2778
p.G927W	TCGA-BQ-7044	KIRP	TCGA	APTSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.G927W	DO20942	KIRP	ICGC	APTSS	DEG_SPOP_SBC_1	934:938	Mutation rewiring degron network	0.1389
p.V660A	TCGA-BR-4361	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1111
p.V660A	DO38887	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1111
p.R777Q	TCGA-BS-A0UV	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.25
p.R777Q	DO42793	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.25
p.E437D	TCGA-BT-A20J	BLCA	TCGA	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.E437D	DO457	BLCA	ICGC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.V978M	TCGA-CG-4442	STAD	TCGA	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7208
p.V978M	DO38380	STAD	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7208
p.V978M	SIDM02017	Colorectal Carcinoma	GDSC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7208
p.E118K	TCGA-D3-A51T	SKCM	TCGA	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.2778
p.E118K	DO47389	SKCM	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.2778
p.D127N	TCGA-DA-A95Y	SKCM	TCGA	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.25
p.D127N	DO223908	SKCM	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.25
p.S778G	TCGA-DF-A2KN	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.2778
p.S778G	DO223282	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.2778
p.S698C	TCGA-E5-A4U1	BLCA	TCGA	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.1111
p.S698C	DO44061	BLCA	ICGC	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.1111
p.P793L	TCGA-EE-A3AG	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.0833
p.P793L	DO37471	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.0833
p.P793L	CP66-MEL	skin	COSMIC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.0833
p.P792S	TCGA-FS-A1Z3	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.P792S	DO37635	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.P655H	TCGA-W3-A828	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.25
p.P655H	DO51273	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.25
p.T639A	TCGA-WS-AB45	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.0833
p.T639A	DO51734	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.0833
p.T114M	DO227536	COCA	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.1667
p.R132Q	DO227979	COCA	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.1111
p.L435F	DO228693	GACA	ICGC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1389
p.N657D	DO233088	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1944
p.S987A	DO233251	GACA	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.1667
p.V985M	DO233616	GACA	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.2222
p.S974C	DO228188	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7541
p.S974I	DO228948	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7341
p.G640V	DO228952	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1111
p.G983V	DO228974	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.2778
p.V969F	DO228971	LICA	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.25
p.D110Y	DO229022	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.0556
p.V772F	DO229024	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.G905V	DO229037	LICA	ICGC	PPGY	ITCH	903:906	Mutation altering degron motif	0.6421
p.G120C	DO229045	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation altering degron motif	0.6489
p.R124Q	DO229050	LICA	ICGC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation altering degron motif	0.6218
p.T696A	DO50796	LIRI	ICGC	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.1667
p.P903L	DO220891	MELA	ICGC	PPGY	ITCH	903:906	Mutation altering degron motif	0.7582
p.P900S	DO220899	MELA	ICGC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.25
p.P792A	DO222731	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.Q436P	DO229490	PRAD	ICGC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1667
p.P793H	DO229211	THCA	ICGC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.0833
p.A981T	DO219784	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7139
p.A981T	DO42280	UCEC	ICGC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation altering degron motif	0.7139
p.Y986H	SIDM02071	Esophageal Carcinoma	GDSC	TSSNTGVPDI	DEG_COP1_1	972:981	Mutation rewiring degron network	0.1944
p.S641P	SIDM00434	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00411	Pancreatic Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00267	Biliary Tract Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00002	Neuroblastoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00290	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00247	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM01569	Hepatocellular Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00167	Head and Neck Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM00160	Biliary Tract Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM01469	Pancreatic Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	SIDM01413	Oral Cavity Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	RERF-LC-KJ	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.S641P	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.V772L	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.V772L	SIDM00090	Ovarian Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.V772L	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.V772L	OVCAR-8	ovary	COSMIC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.1111
p.P655L	SIDM01175	Other Sarcomas	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.25
p.P655L	ACH-002309	Sarcoma	CCLE	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.25
p.P655L	SW684	soft tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.25
p.A901V	SIDM00238	Ovarian Carcinoma	GDSC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.2778
p.A901V	ACH-000947	Ovarian Cancer	CCLE	PPGY	ITCH	903:906	Mutation rewiring degron network	0.2778
p.A901V	OVK-18	ovary	COSMIC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.2778
p.R132L	SIDM00576	Acute Myeloid Leukemia	GDSC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.1111
p.R132L	ACH-002290	Leukemia	CCLE	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.1111
p.R132L	NKM-1	haematopoietic and lymphoid tissue	COSMIC	GKENR	DEG_APCC_KENBOX_2	120:124	Mutation rewiring degron network	0.1111
p.F897V	SIDM00850	Gastric Carcinoma	GDSC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.1667
p.F897V	ACH-000880	Gastric Cancer	CCLE	PPGY	ITCH	903:906	Mutation rewiring degron network	0.1667
p.F897V	AGS	stomach	COSMIC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.1667
p.T659M	SIDM00201	Ewing's Sarcoma	GDSC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.T659M	ACH-002119	Bone Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.T659M	EW-7	bone	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.1389
p.T699A	SIDM01664	Prostate Carcinoma	GDSC	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.T699A	ACH-000952	Prostate Cancer	CCLE	PNTTT	DEG_SPOP_SBC_1	686:690	Mutation rewiring degron network	0.0833
p.S779P	SIDM01409	Bladder Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation rewiring degron network	0.3056
p.N899T	ACH-001453	Prostate Cancer	CCLE	PPGY	ITCH	903:906	Mutation rewiring degron network	0.2222
p.P445L	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	VATST	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7582
p.F908V	AGS	stomach	COSMIC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.2778
p.V783L	OVCAR-8	ovary	COSMIC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation altering degron motif	0.6765
p.V783L	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	780:784	Mutation altering degron motif	0.6765
p.R432H	SNU-1040	large intestine	COSMIC	VATST	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.0556
p.P648L	SW684	soft tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation altering degron motif	0.7582
p.A894V	OVK-18	ovary	COSMIC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.0833
p.S652P	RERF-LC-KJ	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation altering degron motif	0.6752
p.S652P	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation altering degron motif	0.6752
p.T652M	EW-7	bone	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation altering degron motif	0.7423
p.A912V	OVK-18	ovary	COSMIC	PPGY	ITCH	903:906	Mutation rewiring degron network	0.1667
p.A656D	HCT-15	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	648:652	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBAP2L

UniProt ID: Q14157

Entrez ID: 9898

Protein name: Ubiquitin-associated protein 2-like (Protein NICE-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBAP2L in