DegronMD

Uniprot ID: Q14157

Source protein: Ubiquitin-associated protein 2-like

Source gene: UBAP2L

Class: DEG_SPOP_SBC_1

Location: 780:784

E3 ligase: SPOP

DEGRON score: 0.7169

ASA_SCORE: 82.68

COIL: 0.8994

CONS_SCORE: 0.5065

DSS_SCORE: 0.5752

HELIX: 0.022

FCONS_SCORE: 0.9573

RIG_SCORE: 0.6406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R777Q	TCGA-BS-A0UV	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	0.25
p.R777Q	DO42793	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	0.25
p.S778G	TCGA-DF-A2KN	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	0.2778
p.S778G	DO223282	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	0.2778
p.P793L	TCGA-EE-A3AG	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	0.0833
p.P793L	DO37471	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	0.0833
p.P793L	CP66-MEL	skin	COSMIC	VATTS	DEG_SPOP_SBC_1	0.0833
p.P792S	TCGA-FS-A1Z3	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	0.1111
p.P792S	DO37635	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	0.1111
p.V772F	DO229024	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	0.1111
p.P792A	DO222731	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	0.1111
p.P793H	DO229211	THCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.0833
p.V772L	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.1111
p.V772L	SIDM00090	Ovarian Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.1111
p.V772L	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1111
p.V772L	OVCAR-8	ovary	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1111
p.S779P	SIDM01409	Bladder Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.3056
p.V783L	OVCAR-8	ovary	COSMIC	VATTS	DEG_SPOP_SBC_1	0.6765
p.V783L	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons