DegronMD - Q14160(SCRIB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1218L	TCGA-55-6969	LUAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.8428
p.R1218L	TCGA-CV-7090	HNSC	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.8428
p.R1218L	DO14238	HNSC	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.8428
p.R1218L	DO24586	LUAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.8428
p.V1280M	TCGA-60-2724	LUSC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6097
p.V1280M	DO26540	LUSC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6097
p.S1279R	TCGA-63-A5MS	LUSC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.8538
p.S1279R	DO217896	GACA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.8538
p.S1279R	DO219161	LUSC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.8538
p.S1226F	TCGA-AA-3712	COAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation blocking phosphorylation signal	0.75
p.S1226F	DO9780	COAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation blocking phosphorylation signal	0.75
p.E1611K	TCGA-AC-A2BK	BRCA	TCGA	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation rewiring degron network	0.0556
p.E1611K	DO1328	BRCA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation rewiring degron network	0.0556
p.A967T	TCGA-AJ-A3BH	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.2778
p.A967T	DO41638	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.2778
p.G1290R	TCGA-AP-A059	UCEC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.25
p.G1290R	DO41361	UCEC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.25
p.K1570N	TCGA-AP-A0LM	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	1556:1560	Mutation rewiring degron network	0.0556
p.K1570N	DO48414	BLCA	ICGC	PQTST	DEG_SPOP_SBC_1	1556:1560	Mutation rewiring degron network	0.0556
p.K1570N	DO43306	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	1556:1560	Mutation rewiring degron network	0.0556
p.L1271M	TCGA-BQ-7060	KIRP	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1944
p.L1271M	DO20831	KIRP	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1944
p.R1522M	TCGA-BR-4368	STAD	TCGA	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.1389
p.R1522M	DO38715	STAD	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.1389
p.G1214D	TCGA-BR-6452	STAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.25
p.G1214D	DO38404	STAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.25
p.S1225C	TCGA-C5-A7X3	CESC	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.7541
p.S1225C	DO49893	CESC	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.7541
p.A1212V	TCGA-CK-5916	COAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.1944
p.A1212V	DO8786	COAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.1944
p.E1234Q	TCGA-CR-6472	HNSC	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.0833
p.E1234Q	DO15870	HNSC	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.0833
p.L1271V	TCGA-EE-A3AB	SKCM	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1944
p.L1271V	DO222670	MELA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1944
p.L1271V	DO38057	SKCM	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1944
p.S1523F	TCGA-EE-A3JA	SKCM	TCGA	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation blocking phosphorylation signal	0.6111
p.S1523F	DO220860	MELA	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation blocking phosphorylation signal	0.6111
p.S1523F	DO47625	SKCM	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation blocking phosphorylation signal	0.6111
p.R1229L	TCGA-ER-A195	SKCM	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.2222
p.R1229L	TCGA-FS-A1ZQ	SKCM	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.2222
p.R1229L	DO37442	SKCM	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.2222
p.R1229L	DO47712	SKCM	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.2222
p.R1269C	TCGA-EY-A1GU	UCEC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1389
p.R1269C	DO41518	UCEC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1389
p.R1269C	ACH-000619	Head and Neck Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1389
p.G1289R	TCGA-GV-A6ZA	BLCA	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.2778
p.G1289R	DO49776	BLCA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.2778
p.G1290V	TCGA-HE-7130	KIRP	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.25
p.G1290V	DO20776	KIRP	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.25
p.A1212E	TCGA-HF-A5NB	STAD	TCGA	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.1944
p.A1212E	DO50127	STAD	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.1944
p.P1284L	TCGA-IR-A3LK	CESC	TCGA	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.7582
p.P1284L	DO44299	CESC	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.7582
p.A970V	TCGA-VQ-A8P2	STAD	TCGA	VATTS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.5825
p.A970V	DO51761	STAD	ICGC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.5825
p.G980R	DO49258	ALL	ICGC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.G980R	DO228483	BRCA	ICGC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.G980R	DO229013	COCA	ICGC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.G980R	DO229505	LAML	ICGC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.R1269H	DO230343	COCA	ICGC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1389
p.R1218W	DO233882	GACA	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.8634
p.S1638G	DO233823	GACA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation rewiring degron network	0.0833
p.P1562A	DO224740	PACA	ICGC	PQTST	DEG_SPOP_SBC_1	1556:1560	Mutation rewiring degron network	0.2778
p.H1217P	DO35606	PBCA	ICGC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation altering degron motif	0.6583
p.A1628T	DO232761	PBCA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation altering degron motif	0.7139
p.A1628T	SIDM01307	Colorectal Carcinoma	GDSC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation altering degron motif	0.7139
p.A1628T	SIDM00287	B-Lymphoblastic Leukemia	GDSC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation altering degron motif	0.7139
p.S1523Y	DO229218	THCA	ICGC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation blocking phosphorylation signal	0.6111
p.G1630D	DO229234	THCA	ICGC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation blocking phosphorylation signal	0.75
p.S1276G	SIDM00541	Colorectal Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.8104
p.S1276G	ACH-000926	Colon/Colorectal Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.8104
p.G983V	SIDM00588	Oral Cavity Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0556
p.G983V	ACH-000546	Head and Neck Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0556
p.G983V	HSC-4	upper aerodigestive tract	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.0556
p.G1235D	SIDM00884	Breast Carcinoma	GDSC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.0556
p.G1235D	ACH-000699	Breast Cancer	CCLE	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.0556
p.G1235D	HCC1395	breast	COSMIC	HRNSLESIS	DEG_APCC_DBOX_1	1217:1225	Mutation rewiring degron network	0.0556
p.R1527Q	SIDM00113	Kidney Carcinoma	GDSC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2778
p.R1527Q	ACH-001208	Kidney Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2778
p.R1527Q	TK10	kidney	COSMIC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.2778
p.E1632D	SIDM00506	Small Cell Lung Carcinoma	GDSC	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation rewiring degron network	0.25
p.A1270T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1667
p.A1270T	ACH-002256	Leukemia	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1667
p.A1270T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.1667
p.A1277T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	SIDM00282	Colorectal Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	SIDM00358	Gastric Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	SIDM00599	Osteosarcoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	SIDM00997	Thyroid Gland Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	SIDM00302	Other Solid Cancers	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	SIDM01682	Gastric Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-000062	Lung Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-000110	Gastric Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-000144	Gastric Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-000998	Colon/Colorectal Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-001306	Thyroid Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-001526	Bone Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-001610	Brain Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	ACH-002149	Ovarian Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	RERF-LC-MS	lung	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	KGN	ovary	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	CW-2	large intestine	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	RERF-GC-1B	stomach	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	8305C	thyroid	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.A1277T	HuO9	bone	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6028
p.E1538K	SIDM00797	Melanoma	GDSC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.3056
p.E1538K	SIDM00797	Melanoma	GDSC	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation rewiring degron network	0.2222
p.E1538K	ACH-000788	Skin Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.3056
p.E1538K	ACH-000788	Skin Cancer	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation rewiring degron network	0.2222
p.E1538K	A2058	skin	COSMIC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.3056
p.E1538K	A2058	skin	COSMIC	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation rewiring degron network	0.2222
p.P1542L	SIDM00181	Bladder Carcinoma	GDSC	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation altering degron motif	0.6471
p.S962F	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.S962F	ACH-000672	Lung Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.S962F	IA-LM	lung	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.R1282G	SIDM00901	Endometrial Carcinoma	GDSC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6457
p.R1282G	ACH-000940	Endometrial/Uterine Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6457
p.R1282G	AN3-CA	endometrium	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.6457
p.G1526S	SIDM01735	Biliary Tract Carcinoma	GDSC	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.25
p.G1526S	ACH-000808	Bile Duct Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation rewiring degron network	0.25
p.S1614R	ACH-000879	Endometrial/Uterine Cancer	CCLE	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation rewiring degron network	0.1389
p.S1541F	ACH-000931	Skin Cancer	CCLE	TRGPLERLA	DEG_APCC_DBOX_1	1529:1537	Mutation blocking phosphorylation signal	0.6667
p.S1541F	ACH-000931	Skin Cancer	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation blocking phosphorylation signal	0.75
p.T972S	ACH-000932	Gastric Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.6005
p.R1622C	ACH-000940	Endometrial/Uterine Cancer	CCLE	GRRGLGPVP	DEG_APCC_DBOX_1	1621:1629	Mutation altering degron motif	0.8301
p.A1543T	ACH-000995	Leukemia	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation altering degron motif	0.6028
p.T1549P	ACH-001982	Metastasis	CCLE	PAPTPSPT	DEG_SCF_FBW7_1	1542:1549	Mutation altering degron motif	0.8142
p.A1272V	ACH-002396	Bone Cancer	CCLE	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.2222
p.A1272V	Sarc9371	bone	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation rewiring degron network	0.2222
p.Q1277H	NCI-H2110	lung	COSMIC	SAGSVQRVPSGA	DEG_COP1_1	1276:1287	Mutation altering degron motif	0.7582
p.P962L	TK10	kidney	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.P962L	NCI-H69	lung	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1389
p.R963W	HCC1569	breast	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1667
p.V973G	SK-CO-1	large intestine	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation altering degron motif	0.7532
p.R963Q	ME-1	haematopoietic and lymphoid tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1667
p.R963Q	HN	upper aerodigestive tract	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.1667
p.R968C	IM-95	stomach	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.3056
p.R976H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	969:973	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCRIB

UniProt ID: Q14160

Entrez ID: 23513

Protein name: Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCRIB in