DegronMD

Uniprot ID: Q14160

Source protein: Protein scribble homolog

Source gene: SCRIB

Class: DEG_SPOP_SBC_1

Location: 969:973

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 77.9

COIL: 0.867

CONS_SCORE: 0.2989

DSS_SCORE: 0.5744

HELIX: 0.0442

FCONS_SCORE: 0.762

RIG_SCORE: 0.7011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A967T	TCGA-AJ-A3BH	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	0.2778
p.A967T	DO41638	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	0.2778
p.A970V	TCGA-VQ-A8P2	STAD	TCGA	VATTS	DEG_SPOP_SBC_1	0.5825
p.A970V	DO51761	STAD	ICGC	VATTS	DEG_SPOP_SBC_1	0.5825
p.G980R	DO49258	ALL	ICGC	VATTS	DEG_SPOP_SBC_1	0.1389
p.G980R	DO228483	BRCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.1389
p.G980R	DO229013	COCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.1389
p.G980R	DO229505	LAML	ICGC	VATTS	DEG_SPOP_SBC_1	0.1389
p.G983V	SIDM00588	Oral Cavity Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.0556
p.G983V	ACH-000546	Head and Neck Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.0556
p.G983V	HSC-4	upper_aerodigestive_tract	COSMIC	VATTS	DEG_SPOP_SBC_1	0.0556
p.S962F	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.1389
p.S962F	ACH-000672	Lung Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.1389
p.S962F	IA-LM	lung	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1389
p.T972S	ACH-000932	Gastric Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.6005
p.P962L	TK10	kidney	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1389
p.P962L	NCI-H69	lung	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1389
p.R963W	HCC1569	breast	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1667
p.V973G	SK-CO-1	large_intestine	COSMIC	VATTS	DEG_SPOP_SBC_1	0.7532
p.R963Q	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1667
p.R963Q	HN	upper_aerodigestive_tract	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1667
p.R968C	IM-95	stomach	COSMIC	VATTS	DEG_SPOP_SBC_1	0.3056
p.R976H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons