DegronMD

Uniprot ID: O60675

Source protein: Transcription factor MafK

Source gene: MAFK

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.7845

ASA_SCORE: 63.5

COIL: 0.8518

CONS_SCORE: 0.3588

DSS_SCORE: 0.2276

HELIX: 0.0836

FCONS_SCORE: 1.0443

RIG_SCORE: 0.8205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V121M	TCGA-FD-A3SN	BLCA	TCGA	VATTS	DEG_SPOP_SBC_1	0.0556
p.V121M	DO490	BLCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.0556
p.T133I	DO38404	STAD	ICGC	VATTS	DEG_SPOP_SBC_1	0.8189
p.R123Q	SIDM00690	Head and Neck Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.1111
p.V136I	ACH-000943	Colon/Colorectal Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.3056
p.V140I	ACH-000999	Colon/Colorectal Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons