DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 7777:7781

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 80.86

COIL: 0.7958

CONS_SCORE: 0

DSS_SCORE: 0.5316

HELIX: 0.0212

FCONS_SCORE: 0

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S7789Y	TCGA-G4-6298	COAD	TCGA	VATTS	DEG_SPOP_SBC_1	0.1111
p.S7789Y	DO7834	COAD	ICGC	VATTS	DEG_SPOP_SBC_1	0.1111
p.G7774W	TCGA-XF-A8HG	BLCA	TCGA	VATTS	DEG_SPOP_SBC_1	0.25
p.G7774W	DO49802	BLCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.25
p.P7768T	DO229045	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	0.0833
p.K7785N	DO222702	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	0.3333
p.A7778T	DO228772	PBCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.6028
p.S7782F	SIDM00853	Other Sarcomas	GDSC	VATTS	DEG_SPOP_SBC_1	0.3056
p.S7782F	ACH-000835	Sarcoma	CCLE	VATTS	DEG_SPOP_SBC_1	0.3056
p.S7782F	GCT	soft_tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	0.3056
p.T7780P	SIDM01611	Endometrial Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.7031
p.T7780P	ACH-000996	Endometrial/Uterine Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons