DegronMD - Q8IWV7(UBR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T999I	TCGA-19-5956	GBM	TCGA	VATTS	DEG_SPOP_SBC_1	996:1000	Mutation altering degron motif	0.7078
p.T999I	DO13863	GBM	ICGC	VATTS	DEG_SPOP_SBC_1	996:1000	Mutation altering degron motif	0.7078
p.Q1580L	TCGA-50-6590	LUAD	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0556
p.Q1580L	DO24692	LUAD	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0556
p.V1585A	TCGA-B5-A3FC	UCEC	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.1944
p.V1585A	DO41871	UCEC	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.1944
p.A1732D	TCGA-BS-A0UJ	UCEC	TCGA	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.0556
p.A1732D	DO42745	UCEC	ICGC	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.0556
p.R1589I	TCGA-CA-6717	COAD	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.3056
p.R1589I	DO8264	COAD	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.3056
p.R1591I	TCGA-DF-A2KV	UCEC	TCGA	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.8102
p.R1591I	DO219771	UCEC	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.8102
p.R987Q	TCGA-W3-AA21	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	996:1000	Mutation rewiring degron network	0.0833
p.R987Q	DO51278	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	996:1000	Mutation rewiring degron network	0.0833
p.L1597I	DO229015	LICA	ICGC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.6063
p.T998I	DO222409	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	996:1000	Mutation altering degron motif	0.7078
p.G1001V	DO222875	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	996:1000	Mutation rewiring degron network	0.3056
p.S1734R	SIDM00773	Non-Cancerous	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.1111
p.S1734R	SIDM00210	Ovarian Carcinoma	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.1111
p.S1734R	SIDM01112	Osteosarcoma	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.1111
p.S1734R	SIDM01664	Prostate Carcinoma	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.1111
p.I1595L	SIDM01045	Endometrial Carcinoma	GDSC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.6063
p.I1595L	ACH-000978	Endometrial/Uterine Cancer	CCLE	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.6063
p.I1595L	EN	endometrium	COSMIC	KRNSLIELP	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.6063
p.S1734T	ACH-000961	Endometrial/Uterine Cancer	CCLE	FGFNWQLL	DEG_MDM2_SWIB_1	1742:1749	Mutation rewiring degron network	0.1111

Kaplan plot for UBR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBR1

UniProt ID: Q8IWV7

Entrez ID: 197131

Protein name: E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBR1 in