DegronMD

Uniprot ID: Q8IWV7

Source protein: E3 ubiquitin-protein ligase UBR1

Source gene: UBR1

Class: DEG_MDM2_SWIB_1

Location: 1742:1749

E3 ligase: MDM2

DEGRON score: 0.913

ASA_SCORE: 100.125

COIL: 0.779

CONS_SCORE: 0.2214

DSS_SCORE: 0.3622

HELIX: 0.1354

FCONS_SCORE: 0.6631

RIG_SCORE: 0.8944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1732D	TCGA-BS-A0UJ	UCEC	TCGA	FGFNWQLL	DEG_MDM2_SWIB_1	0.0556
p.A1732D	DO42745	UCEC	ICGC	FGFNWQLL	DEG_MDM2_SWIB_1	0.0556
p.S1734R	SIDM00773	Non-Cancerous	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	0.1111
p.S1734R	SIDM00210	Ovarian Carcinoma	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	0.1111
p.S1734R	SIDM01112	Osteosarcoma	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	0.1111
p.S1734R	SIDM01664	Prostate Carcinoma	GDSC	FGFNWQLL	DEG_MDM2_SWIB_1	0.1111
p.S1734T	ACH-000961	Endometrial/Uterine Cancer	CCLE	FGFNWQLL	DEG_MDM2_SWIB_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_MDM2_SWIB_1	1742:1749	FGFNWQLL	MDM2	0.913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons