DegronMD

Uniprot ID: Q8IWV7

Source protein: E3 ubiquitin-protein ligase UBR1

Source gene: UBR1

Class: DEG_SPOP_SBC_1

Location: 996:1000

E3 ligase: SPOP

DEGRON score: 0.5572

ASA_SCORE: 55.84

COIL: 0.366

CONS_SCORE: 0.2878

DSS_SCORE: 0.3548

HELIX: 0.1376

FCONS_SCORE: 0.9045

RIG_SCORE: 0.7646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T999I	TCGA-19-5956	GBM	TCGA	VATTS	DEG_SPOP_SBC_1	0.7078
p.T999I	DO13863	GBM	ICGC	VATTS	DEG_SPOP_SBC_1	0.7078
p.R987Q	TCGA-W3-AA21	SKCM	TCGA	VATTS	DEG_SPOP_SBC_1	0.0833
p.R987Q	DO51278	SKCM	ICGC	VATTS	DEG_SPOP_SBC_1	0.0833
p.T998I	DO222409	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	0.7078
p.G1001V	DO222875	MELA	ICGC	VATTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons