DegronMD - Q6PI98(INO80C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I7F	TCGA-D1-A0ZO	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.I7F	DO41927	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.I7V	TCGA-VR-A8EU	ESCA	TCGA	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.E6D	DO10880	GBM	ICGC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.2778
p.S20R	DO228908	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.5556
p.A2E	DO229045	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6111
p.T11S	DO35609	PBCA	ICGC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.6005
p.V17L	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1944
p.V17L	ACH-000438	Lung Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1944
p.V17L	LU-65	lung	COSMIC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1944
p.A2V	SIDM00217	Colorectal Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6111
p.A2V	ACH-000999	Colon/Colorectal Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6111
p.A2V	SNU-1040	large intestine	COSMIC	VATTS	DEG_SPOP_SBC_1	8:12	Mutation blocking phosphorylation signal	0.6111
p.A22V	ACH-000013	Ovarian Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	8:12	Mutation blocking ubiquitination signal	0.5
p.T10I	ACH-000628	Lung Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7078
p.V10A	ACH-000996	Endometrial/Uterine Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.6936

Kaplan plot for INO80C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INO80C

UniProt ID: Q6PI98

Entrez ID: 125476

Protein name: INO80 complex subunit C (IES6 homolog) (hIes6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INO80C in