DegronMD

Uniprot ID: Q6PI98

Source protein: INO80 complex subunit C

Source gene: INO80C

Class: DEG_SPOP_SBC_1

Location: 8:12

E3 ligase: SPOP

DEGRON score: 0.9604

ASA_SCORE: 70.98

COIL: 0.6858

CONS_SCORE: 0.3385

DSS_SCORE: 0.5651

HELIX: 0.019

FCONS_SCORE: 0.9369

RIG_SCORE: 0.7601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I7F	TCGA-D1-A0ZO	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	0.3056
p.I7F	DO41927	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	0.3056
p.I7V	TCGA-VR-A8EU	ESCA	TCGA	VATTS	DEG_SPOP_SBC_1	0.3056
p.E6D	DO10880	GBM	ICGC	VATTS	DEG_SPOP_SBC_1	0.2778
p.S20R	DO228908	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	0.5556
p.A2E	DO229045	LICA	ICGC	VATTS	DEG_SPOP_SBC_1	0.6111
p.T11S	DO35609	PBCA	ICGC	VATTS	DEG_SPOP_SBC_1	0.6005
p.V17L	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.1944
p.V17L	ACH-000438	Lung Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.1944
p.V17L	LU-65	lung	COSMIC	VATTS	DEG_SPOP_SBC_1	0.1944
p.A2V	SIDM00217	Colorectal Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.6111
p.A2V	ACH-000999	Colon/Colorectal Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.6111
p.A2V	SNU-1040	large_intestine	COSMIC	VATTS	DEG_SPOP_SBC_1	0.6111
p.A22V	ACH-000013	Ovarian Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.5
p.T10I	ACH-000628	Lung Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.7078
p.V10A	ACH-000996	Endometrial/Uterine Cancer	CCLE	VATTS	DEG_SPOP_SBC_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons