DegronMD

Uniprot ID: Q13608

Source protein: Peroxisome assembly factor 2

Source gene: PEX6

Class: DEG_SPOP_SBC_1

Location: 570:574

E3 ligase: SPOP

DEGRON score: 0.5702

ASA_SCORE: 13.46

COIL: 0.286

CONS_SCORE: 0.5836

DSS_SCORE: 0.3459

HELIX: 0.004

FCONS_SCORE: 1.289

RIG_SCORE: 0.789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R575Q	TCGA-AJ-A3EK	UCEC	TCGA	VATTS	DEG_SPOP_SBC_1	0.3056
p.R575Q	DO41584	UCEC	ICGC	VATTS	DEG_SPOP_SBC_1	0.3056
p.Q584H	TCGA-C5-A7UC	CESC	TCGA	VATTS	DEG_SPOP_SBC_1	0.0556
p.Q584H	DO49889	CESC	ICGC	VATTS	DEG_SPOP_SBC_1	0.0556
p.T573I	SIDM00669	Pancreatic Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	0.7078
p.T573I	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VATTS	DEG_SPOP_SBC_1	0.7078
p.T573I	SIDM00887	Other Solid Cancers	GDSC	VATTS	DEG_SPOP_SBC_1	0.7078
p.D582N	ACH-000923	Lymphoma	CCLE	VATTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60675	Transcription factor MafK	DEG_SPOP_SBC_1	131:135	VATTS	SPOP	0.7845	More...
Q13608	Peroxisome assembly factor 2	DEG_SPOP_SBC_1	570:574	VATTS	SPOP	0.5702	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	780:784	VATTS	SPOP	0.7169	More...
Q14160	Protein scribble homolog	DEG_SPOP_SBC_1	969:973	VATTS	SPOP	0.9963	More...
Q6PI98	INO80 complex subunit C	DEG_SPOP_SBC_1	8:12	VATTS	SPOP	0.9604	More...
Q8IWV7	E3 ubiquitin-protein ligase UBR1	DEG_SPOP_SBC_1	996:1000	VATTS	SPOP	0.5572	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7777:7781	VATTS	SPOP	0.9972	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	345:349	VATTS	SPOP	0.7691	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1268:1272	VATTS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons