DegronMD - Q9Y6J0(CABIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2046L	TCGA-BR-8382	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.3056
p.P2046L	DO47925	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.3056
p.P2036L	TCGA-DF-A2KU	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.1944
p.A336T	TCGA-DU-6392	LGG	TCGA	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.A336T	DO22237	LGG	ICGC	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.A336T	DO232224	PBCA	ICGC	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.A336T	SIDM01278	Colorectal Carcinoma	GDSC	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.A336T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.A336T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.V335G	DO48365	BLCA	ICGC	VATTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0556
p.A1821T	DO228902	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.25
p.R2044L	DO229018	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation altering degron motif	0.8428
p.H1832R	DO44982	LIHC	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.2222
p.T1826I	DO231655	LINC	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.7078
p.K2039T	DO220211	SARC	ICGC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.2778
p.A1821P	DO219881	SKCA	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.25
p.A1821P	DO229232	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.25
p.E1837V	DO229253	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.0833
p.R1831G	DO229211	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.25
p.A1825T	DO229250	THCA	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation altering degron motif	0.6028
p.L1833R	DO41644	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	1824:1828	Mutation rewiring degron network	0.1944
p.P2042S	SIDM00853	Other Sarcomas	GDSC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation altering degron motif	0.5641
p.P2042S	GCT	soft tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation altering degron motif	0.5641
p.S2043N	ACH-000984	Endometrial/Uterine Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation altering degron motif	0.7069
p.P2046Q	TGBC11TKB	stomach	COSMIC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.3056
p.T2047S	RERF-LC-FM	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.2778
p.T2047S	RCM-1	large intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.2778
p.P2054L	TT	thyroid	COSMIC	APTSS	DEG_SPOP_SBC_1	2041:2045	Mutation rewiring degron network	0.0833

Kaplan plot for CABIN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CABIN1

UniProt ID: Q9Y6J0

Entrez ID: 23523

Protein name: Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CABIN1 in