DegronMD

Uniprot ID: Q9Y6J0

Source protein: Calcineurin-binding protein cabin-1

Source gene: CABIN1

Class: DEG_SPOP_SBC_1

Location: 2041:2045

E3 ligase: SPOP

DEGRON score: 0.9949

ASA_SCORE: 85.54

COIL: 0.971

CONS_SCORE: 0.2607

DSS_SCORE: 0.6247

HELIX: 0.0108

FCONS_SCORE: 0.8995

RIG_SCORE: 0.5634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2046L	TCGA-BR-8382	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.3056
p.P2046L	DO47925	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.3056
p.P2036L	TCGA-DF-A2KU	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	0.1944
p.R2044L	DO229018	LICA	ICGC	APTSS	DEG_SPOP_SBC_1	0.8428
p.K2039T	DO220211	SARC	ICGC	APTSS	DEG_SPOP_SBC_1	0.2778
p.P2042S	SIDM00853	Other Sarcomas	GDSC	APTSS	DEG_SPOP_SBC_1	0.5641
p.P2042S	GCT	soft_tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	0.5641
p.S2043N	ACH-000984	Endometrial/Uterine Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.7069
p.P2046Q	TGBC11TKB	stomach	COSMIC	APTSS	DEG_SPOP_SBC_1	0.3056
p.T2047S	RERF-LC-FM	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	0.2778
p.T2047S	RCM-1	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.2778
p.P2054L	TT	thyroid	COSMIC	APTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	934:938	APTSS	SPOP	0.9885	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	325:329	APTSS	SPOP	0.9804	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
O60268	Uncharacterized protein KIAA0513	DEG_SPOP_SBC_1	18:22	APTSS	SPOP	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with CABIN1 mutations

All proteins holding degron of APTSS