DegronMD - O60393(NOBOX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R227H	TCGA-BR-4370	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1111
p.R227H	DO38499	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1111
p.R227H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1111
p.R227H	REH	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1111
p.N210D	TCGA-BS-A0TA	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1944
p.N210D	DO43298	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1944
p.R227C	TCGA-CG-4306	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1111
p.R227C	DO38567	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1111
p.S225L	TCGA-EE-A2M5	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1667
p.S225L	DO222423	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1667
p.S225L	DO37425	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1667
p.A215T	DO233882	GACA	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7139
p.P216A	DO50681	ORCA	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.6392
p.T217A	DO232761	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7139
p.P216S	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.5641
p.P216S	ACH-000666	Lung Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.5641
p.P216S	NCI-H1355	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.5641
p.A215P	SIDM00282	Colorectal Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.6392
p.A215P	ACH-000998	Colon/Colorectal Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.6392
p.A215P	CW-2	large intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.6392
p.K205R	ACH-001563	Skin Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	215:219	Mutation substituting flanking lysine	0.1667
p.R217S	SW1271	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7427
p.R218Q	NCI-H740	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7329
p.A221D	AMO-1	haematopoietic and lymphoid tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.2778

Kaplan plot for NOBOX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOBOX

UniProt ID: O60393

Entrez ID: 135935

Protein name: Homeobox protein NOBOX

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOBOX in