DegronMD

Uniprot ID: O60393

Source protein: Homeobox protein NOBOX

Source gene: NOBOX

Class: DEG_SPOP_SBC_1

Location: 215:219

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 68.92

COIL: 0.922

CONS_SCORE: 0.3435

DSS_SCORE: 0.6737

HELIX: 0.0252

FCONS_SCORE: 1.0355

RIG_SCORE: 0.5804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R227H	TCGA-BR-4370	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.1111
p.R227H	DO38499	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.1111
p.R227H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	APTSS	DEG_SPOP_SBC_1	0.1111
p.R227H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	0.1111
p.N210D	TCGA-BS-A0TA	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	0.1944
p.N210D	DO43298	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	0.1944
p.R227C	TCGA-CG-4306	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	0.1111
p.R227C	DO38567	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	0.1111
p.S225L	TCGA-EE-A2M5	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	0.1667
p.S225L	DO222423	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.S225L	DO37425	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	0.1667
p.A215T	DO233882	GACA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7139
p.P216A	DO50681	ORCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.6392
p.T217A	DO232761	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	0.7139
p.P216S	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.5641
p.P216S	ACH-000666	Lung Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.5641
p.P216S	NCI-H1355	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	0.5641
p.A215P	SIDM00282	Colorectal Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	0.6392
p.A215P	ACH-000998	Colon/Colorectal Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.6392
p.A215P	CW-2	large_intestine	COSMIC	APTSS	DEG_SPOP_SBC_1	0.6392
p.K205R	ACH-001563	Skin Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	0.1667
p.R217S	SW1271	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	0.7427
p.R218Q	NCI-H740	lung	COSMIC	APTSS	DEG_SPOP_SBC_1	0.7329
p.A221D	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	APTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43432	Eukaryotic translation initiation factor 4 gamma 3	DEG_SPOP_SBC_1	281:285	APTSS	SPOP	0.9619	More...
O60393	Homeobox protein NOBOX	DEG_SPOP_SBC_1	215:219	APTSS	SPOP	0.9981	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	162:166	APTSS	SPOP	0.9993	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	217:221	APTSS	SPOP	0.9984	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	228:232	APTSS	SPOP	0.9572	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2335:2339	APTSS	SPOP	0.9594	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2423:2427	APTSS	SPOP	0.7877	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2919:2923	APTSS	SPOP	0.9435	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3409:3413	APTSS	SPOP	0.9913	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3417:3421	APTSS	SPOP	0.9924	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3457:3461	APTSS	SPOP	0.6097	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3723:3727	APTSS	SPOP	0.7478	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3858:3862	APTSS	SPOP	0.9833	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4284:4288	APTSS	SPOP	0.9949	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	934:938	APTSS	SPOP	0.9885	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1528:1532	APTSS	SPOP	0.9822	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	723:727	APTSS	SPOP	0.7462	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	325:329	APTSS	SPOP	0.9804	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1101:1105	APTSS	SPOP	0.9863	More...
Q99966	Cbp/p300-interacting transactivator 1	DEG_SPOP_SBC_1	60:64	APTSS	SPOP	0.9991	More...
Q9BRQ6	MICOS complex subunit MIC25	DEG_SPOP_SBC_1	47:51	APTSS	SPOP	0.8935	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	44:48	APTSS	SPOP	0.7194	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	513:517	APTSS	SPOP	0.9702	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	259:263	APTSS	SPOP	0.9932	More...
Q9UNN5	FAS-associated factor 1	DEG_SPOP_SBC_1	75:79	APTSS	SPOP	0.9907	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	412:416	APTSS	SPOP	0.9247	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	2041:2045	APTSS	SPOP	0.9949	More...
O60268	Uncharacterized protein KIAA0513	DEG_SPOP_SBC_1	18:22	APTSS	SPOP	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTSS

Degron related mutations and impact score

Drug responses associated with NOBOX mutations

All proteins holding degron of APTSS