DegronMD - P10275(AR)

GO - Biological processes (BP): activation of prostate induction by androgen receptor signaling pathway [GO:0060520]; androgen receptor signaling pathway [GO:0030521]; animal organ formation [GO:0048645]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to testosterone stimulus [GO:0071394]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; epithelial cell morphogenesis [GO:0003382]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular receptor signaling pathway [GO:0030522]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; in utero embryonic development [GO:0001701]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; Leydig cell differentiation [GO:0033327]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; male somatic sex determination [GO:0019102]; mammary gland alveolus development [GO:0060749]; morphogenesis of an epithelial fold [GO:0060571]; multicellular organism growth [GO:0035264]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation involved in prostate gland development [GO:0060769]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of integrin biosynthetic process [GO:0045726]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prostate gland epithelium morphogenesis [GO:0060740]; prostate gland growth [GO:0060736]; regulation of developmental growth [GO:0048638]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of systemic arterial blood pressure [GO:0003073]; regulation of transcription by RNA polymerase II [GO:0006357]; seminiferous tubule development [GO:0072520]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A211V	TCGA-36-2533	OV	TCGA	APTSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.A211V	DO32516	OV	ICGC	APTSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.A211T	TCGA-AA-A01P	COAD	TCGA	APTSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.A211T	DO8642	COAD	ICGC	APTSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1667
p.K222N	TCGA-B5-A0JY	UCEC	TCGA	APTSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.K222N	DO43041	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.E645K	TCGA-FW-A3R5	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.E645K	DO37406	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.3056
p.G636C	TCGA-MN-A4N4	LUAD	TCGA	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0556
p.G636C	DO26250	LUAD	ICGC	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.0556
p.P218S	DO220877	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.5641
p.P218L	DO220877	MELA	ICGC	APTSS	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6471
p.S434F	DO222662	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7982
p.S434F	SIDM01169	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7982
p.E442K	DO46358	OV	ICGC	AASSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1111
p.Q641H	SIDM00193	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.Q641H	ACH-000991	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.Q641H	SNU-81	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.1944
p.G434W	C-33-A	cervix	COSMIC	AASSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.7825
p.F644L	CAL-62	thyroid	COSMIC	ASSTT	DEG_SPOP_SBC_1	646:650	Mutation rewiring degron network	0.2778
p.K420R	JHH-4	liver	COSMIC	AASSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AR

UniProt ID: P10275

Entrez ID: 367

Protein name: Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AR in