DegronMD

Uniprot ID: P10275

Source protein: Androgen receptor

Source gene: AR

Class: DEG_SPOP_SBC_1

Location: 430:434

E3 ligase: SPOP

DEGRON score: 0.9407

ASA_SCORE: 61.22

COIL: 0.8024

CONS_SCORE: 0.4082

DSS_SCORE: 0.521

HELIX: 0.1462

FCONS_SCORE: 0.9889

RIG_SCORE: 0.6523

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S434F	DO222662	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	0.7982
p.S434F	SIDM01169	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	0.7982
p.E442K	DO46358	OV	ICGC	AASSS	DEG_SPOP_SBC_1	0.1111
p.G434W	C-33-A	cervix	COSMIC	AASSS	DEG_SPOP_SBC_1	0.7825
p.K420R	JHH-4	liver	COSMIC	AASSS	DEG_SPOP_SBC_1	0.0556

Drug responses associated with AR mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00687	STAD\|stomach	p.E666K (No)	GDSC	AZD3514	107.2435
SIDM00720	MESO\|mesothelioma	p.T559S (No)	GDSC	Bicalutamide	23.3521
SIDM00720	MESO\|mesothelioma	p.T559S (No)	GDSC	AZD3514	24.9412
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.T282S (No)	GDSC	AZD3514	21.4569
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.T282S (No)	GDSC	Bicalutamide	90.3701
SIDM00931	THCA\|thyroid	p.F827L (No)	GDSC	Bicalutamide	14.3028
SIDM00931	THCA\|thyroid	p.F827L (No)	GDSC	AZD3514	8.3404
SIDM00931	THCA\|thyroid	p.F827L (No)	GDSC	Bicalutamide	87.3317
SIDM00213	THCA\|thyroid	p.A270T (No)	GDSC	Bicalutamide	15.121
SIDM00213	THCA\|thyroid	p.A270T (No)	GDSC	AZD3514	26.5149
SIDM00213	THCA\|thyroid	p.A270T (No)	GDSC	Bicalutamide	69.4917
SIDM00499	PRAD\|prostate	p.H875Y (No)	GDSC	Bicalutamide	9.9598
SIDM00499	PRAD\|prostate	p.H875Y (No)	GDSC	AZD3514	22.1595
SIDM00499	PRAD\|prostate	p.H875Y (No)	GDSC	Bicalutamide	155.6449
SIDM00683	PRAD\|prostate	p.K593E (No)	GDSC	Bicalutamide	10.3299
SIDM00683	PRAD\|prostate	p.K593E (No)	GDSC	AZD3514	6.6898
SIDM00683	PRAD\|prostate	p.K593E (No)	GDSC	Bicalutamide	13.4612
SIDM00683	PRAD\|prostate	p.T878A (No)	GDSC	Bicalutamide	10.3299
SIDM00683	PRAD\|prostate	p.T878A (No)	GDSC	AZD3514	6.6898
SIDM00683	PRAD\|prostate	p.T878A (No)	GDSC	Bicalutamide	13.4612
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	6.1747
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	AZD3514	21.3658
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	70.4477
SIDM00453	PAAD\|pancreas	p.L548F (No)	GDSC	Bicalutamide	12.4442
SIDM00453	PAAD\|pancreas	p.L548F (No)	GDSC	AZD3514	8.355
SIDM00453	PAAD\|pancreas	p.L548F (No)	GDSC	Bicalutamide	32.6021
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	16.1827
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	AZD3514	32.1642
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	148.5768
SIDM00393	STAD\|stomach	p.A385S (No)	GDSC	AZD3514	31.3409
SIDM00393	STAD\|stomach	p.A385S (No)	GDSC	Bicalutamide	59.4103
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	7.6848
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	AZD3514	20.33
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	71.0099
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.P392S (No)	GDSC	Bicalutamide	16.9193
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.P392S (No)	GDSC	AZD3514	20.9852
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.P392S (No)	GDSC	Bicalutamide	70.8216
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	13.0587
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	AZD3514	12.8729
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	70.3036
SIDM00239	KIRC\|kidney	p.Y514H (No)	GDSC	Bicalutamide	19.1622
SIDM00239	KIRC\|kidney	p.Y514H (No)	GDSC	AZD3514	91.5292
SIDM00239	KIRC\|kidney	p.Y514H (No)	GDSC	Bicalutamide	227.6454
SIDM00484	THCA\|thyroid	p.P392S (No)	GDSC	Bicalutamide	42.2008
SIDM00484	THCA\|thyroid	p.P392S (No)	GDSC	AZD3514	37.1772
SIDM00484	THCA\|thyroid	p.P392S (No)	GDSC	Bicalutamide	207.8642
SIDM00577	NB\|neuroblastoma	p.D354E (No)	GDSC	Bicalutamide	16.2078
SIDM00577	NB\|neuroblastoma	p.D354E (No)	GDSC	AZD3514	50.4555
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.V716L (No)	GDSC	Bicalutamide	16.6193
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.V716L (No)	GDSC	AZD3514	28.6147
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.V716L (No)	GDSC	Bicalutamide	39.8131
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	9.1072
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	AZD3514	34.4153
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	64.7057
SIDM00217	COREAD\|large_intestine	p.E32K (No)	GDSC	AZD3514	85.3921
SIDM00217	COREAD\|large_intestine	p.E32K (No)	GDSC	Bicalutamide	110.8292
SIDM00217	COREAD\|large_intestine	p.R775H (No)	GDSC	AZD3514	85.3921
SIDM00217	COREAD\|large_intestine	p.R775H (No)	GDSC	Bicalutamide	110.8292
SIDM00217	COREAD\|large_intestine	p.T851A (No)	GDSC	AZD3514	85.3921
SIDM00217	COREAD\|large_intestine	p.T851A (No)	GDSC	Bicalutamide	110.8292
SIDM00140	SKCM\|melanoma	p.P555L (No)	GDSC	Bicalutamide	16.1961
SIDM00140	SKCM\|melanoma	p.P555L (No)	GDSC	AZD3514	25.1651
SIDM00140	SKCM\|melanoma	p.P555L (No)	GDSC	Bicalutamide	154.7129
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	11.3736
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	AZD3514	6.1296
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	24.1556
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.A588S (No)	GDSC	Bicalutamide	14.5368
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.A588S (No)	GDSC	AZD3514	27.7026
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.A588S (No)	GDSC	Bicalutamide	127.1966
SIDM00567	MB\|medulloblastoma	p.Y514H (No)	GDSC	Bicalutamide	14.4072
SIDM00567	MB\|medulloblastoma	p.Y514H (No)	GDSC	AZD3514	31.4925
SIDM00567	MB\|medulloblastoma	p.Y514H (No)	GDSC	Bicalutamide	77.6133
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V912I (No)	GDSC	Bicalutamide	7.0416
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V912I (No)	GDSC	AZD3514	73.7135
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V912I (No)	GDSC	Bicalutamide	81.8414
SIDM00359	COREAD\|large_intestine	p.G334R (No)	GDSC	Bicalutamide	25.7032
SIDM00359	COREAD\|large_intestine	p.G334R (No)	GDSC	AZD3514	58.9207
SIDM00359	COREAD\|large_intestine	p.G334R (No)	GDSC	Bicalutamide	176.7793
SIDM00125	KIRC\|kidney	p.S598G (No)	GDSC	Bicalutamide	8.853
SIDM00125	KIRC\|kidney	p.S598G (No)	GDSC	AZD3514	45.7693
SIDM00125	KIRC\|kidney	p.S598G (No)	GDSC	Bicalutamide	74.3852
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.Q592H (No)	GDSC	Bicalutamide	6.6391
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.Q592H (No)	GDSC	AZD3514	71.9949
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.Q592H (No)	GDSC	Bicalutamide	83.782
SIDM00534	COREAD\|large_intestine	p.A871V (No)	GDSC	Bicalutamide	13.3911
SIDM00534	COREAD\|large_intestine	p.A871V (No)	GDSC	AZD3514	81.503
SIDM00534	COREAD\|large_intestine	p.A871V (No)	GDSC	Bicalutamide	31.9378
SIDM00861	UNCLASSIFIED\|ovary	p.E707K (No)	GDSC	Bicalutamide	8.2473
SIDM00861	UNCLASSIFIED\|ovary	p.E707K (No)	GDSC	AZD3514	29.3747
SIDM00861	UNCLASSIFIED\|ovary	p.E707K (No)	GDSC	Bicalutamide	93.5657
SIDM00850	STAD\|stomach	p.E773V (No)	GDSC	Bicalutamide	10.1759
SIDM00850	STAD\|stomach	p.E773V (No)	GDSC	AZD3514	28.3881
SIDM00545	SKCM\|melanoma	p.E523D (No)	GDSC	Bicalutamide	24.6121
SIDM00545	SKCM\|melanoma	p.E523D (No)	GDSC	AZD3514	58.7699
SIDM00545	SKCM\|melanoma	p.E523D (No)	GDSC	Bicalutamide	179.0194
SIDM00142	UCEC\|endometrium	p.G525fs*37 (No)	GDSC	Bicalutamide	14.4538
SIDM00142	UCEC\|endometrium	p.G525fs*37 (No)	GDSC	AZD3514	45.3914
SIDM00142	UCEC\|endometrium	p.G525fs*37 (No)	GDSC	Bicalutamide	152.1623
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.S244L (No)	GDSC	Bicalutamide	13.9369
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.S244L (No)	GDSC	AZD3514	11.6293
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.S244L (No)	GDSC	Bicalutamide	88.0343
SIDM00616	LIHC\|liver	p.K610R (No)	GDSC	Bicalutamide	8.2531
SIDM00616	LIHC\|liver	p.K610R (No)	GDSC	AZD3514	14.288
SIDM00616	LIHC\|liver	p.K610R (No)	GDSC	Bicalutamide	61.8995
SIDM00328	ESCA\|oesophagus	p.D733N (No)	GDSC	Bicalutamide	24.2256
SIDM00328	ESCA\|oesophagus	p.D733N (No)	GDSC	AZD3514	85.7849
SIDM00328	ESCA\|oesophagus	p.D733N (No)	GDSC	Bicalutamide	182.5489
SIDM00895	DLBC\|B_cell_lymphoma	p.E323K (No)	GDSC	Bicalutamide	6.7861
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	13.0344
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	AZD3514	4.8095
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	114.6281
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L249M (No)	GDSC	Bicalutamide	44.3943
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L249M (No)	GDSC	AZD3514	129.1198
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L249M (No)	GDSC	Bicalutamide	196.849
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.G329C (No)	GDSC	Bicalutamide	15.8164
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.G329C (No)	GDSC	AZD3514	16.2666
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.G329C (No)	GDSC	Bicalutamide	110.66
SIDM00537	COREAD\|large_intestine	p.Y552H (No)	GDSC	Bicalutamide	9.8937
SIDM00537	COREAD\|large_intestine	p.Y552H (No)	GDSC	AZD3514	34.4877
SIDM00537	COREAD\|large_intestine	p.Y552H (No)	GDSC	Bicalutamide	89.9366
SIDM01040	OV\|ovary	p.C602Y (No)	GDSC	Bicalutamide	16.6168
SIDM01040	OV\|ovary	p.C602Y (No)	GDSC	AZD3514	15.0872
SIDM01040	OV\|ovary	p.C602Y (No)	GDSC	Bicalutamide	192.3216
SIDM00054	PAAD\|pancreas	p.D354E (No)	GDSC	Bicalutamide	12.4863
SIDM00054	PAAD\|pancreas	p.D354E (No)	GDSC	Bicalutamide	122.38
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	4.5387
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	AZD3514	23.9848
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	66.6243
SIDM00193	COREAD\|large_intestine	p.Q641H (No)	GDSC	AZD3514	129.7398
SIDM00193	COREAD\|large_intestine	p.Q641H (No)	GDSC	Bicalutamide	103.79
SIDM00193	COREAD\|large_intestine	p.P818S (No)	GDSC	AZD3514	129.7398
SIDM00193	COREAD\|large_intestine	p.P818S (No)	GDSC	Bicalutamide	103.79
SIDM00118	COREAD\|large_intestine	p.R711G (No)	GDSC	Bicalutamide	13.0412
SIDM00118	COREAD\|large_intestine	p.R711G (No)	GDSC	AZD3514	61.1386
SIDM00118	COREAD\|large_intestine	p.R711G (No)	GDSC	Bicalutamide	82.5525
SIDM00118	COREAD\|large_intestine	p.E830* (No)	GDSC	Bicalutamide	13.0412
SIDM00118	COREAD\|large_intestine	p.E830* (No)	GDSC	AZD3514	61.1386
SIDM00118	COREAD\|large_intestine	p.E830* (No)	GDSC	Bicalutamide	82.5525
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.A810P (No)	GDSC	Bicalutamide	20.5506
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.A810P (No)	GDSC	AZD3514	50.1711
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.A810P (No)	GDSC	Bicalutamide	112.6285

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00499	Myc box-dependent-interacting protein 1	DEG_SPOP_SBC_1	485:489	AASSS	SPOP	0.8705	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	49:53	AASSS	SPOP	0.9937	More...
O15553	Pyrin	DEG_SPOP_SBC_1	105:109	AASSS	SPOP	0.7892	More...
O60248	Protein SOX-15	DEG_SPOP_SBC_1	22:26	AASSS	SPOP	0.9164	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	136:140	AASSS	SPOP	0.9558	More...
O60583	Cyclin-T2	DEG_SPOP_SBC_1	472:476	AASSS	SPOP	0.9676	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	659:663	AASSS	SPOP	0.6805	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	912:916	AASSS	SPOP	0.9916	More...
O95568	Histidine protein methyltransferase 1 homolog	DEG_SPOP_SBC_1	81:85	AASSS	SPOP	0.9977	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	430:434	AASSS	SPOP	0.9407	More...
P20585	DNA mismatch repair protein Msh3	DEG_SPOP_SBC_1	12:16	AASSS	SPOP	0.986	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	679:683	AASSS	SPOP	0.9948	More...
P22004	Bone morphogenetic protein 6	DEG_SPOP_SBC_1	165:169	AASSS	SPOP	0.8116	More...
P30305	M-phase inducer phosphatase 2	DEG_SPOP_SBC_1	184:188	AASSS	SPOP	0.9962	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	1033:1037	AASSS	SPOP	0.9986	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1289:1293	AASSS	SPOP	0.9466	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1650:1654	AASSS	SPOP	0.9741	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	559:563	AASSS	SPOP	0.6475	More...
P43357	Melanoma-associated antigen 3	DEG_SPOP_SBC_1	38:42	AASSS	SPOP	0.9939	More...
P43360	Melanoma-associated antigen 6	DEG_SPOP_SBC_1	38:42	AASSS	SPOP	0.9773	More...
P43361	Melanoma-associated antigen 8	DEG_SPOP_SBC_1	38:42	AASSS	SPOP	0.7662	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1026:1030	AASSS	SPOP	0.5327	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	898:902	AASSS	SPOP	0.9984	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	384:388	AASSS	SPOP	0.991	More...
P55316	Forkhead box protein G1	DEG_SPOP_SBC_1	438:442	AASSS	SPOP	0.9093	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	250:254	AASSS	SPOP	0.9841	More...
P61927	60S ribosomal protein L37	DEG_SPOP_SBC_1	92:96	AASSS	SPOP	0.9084	More...
Q01831	DNA repair protein complementing XP-C cells	DEG_SPOP_SBC_1	499:503	AASSS	SPOP	0.9944	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	1138:1142	AASSS	SPOP	0.7435	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	83:87	AASSS	SPOP	0.9662	More...
Q12837	POU domain, class 4, transcription factor 2	DEG_SPOP_SBC_1	153:157	AASSS	SPOP	0.983	More...
Q12952	Forkhead box protein L1	DEG_SPOP_SBC_1	299:303	AASSS	SPOP	0.7842	More...
Q13724	Mannosyl-oligosaccharide glucosidase	DEG_SPOP_SBC_1	732:736	AASSS	SPOP	0.5289	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	214:218	AASSS	SPOP	0.9951	More...
Q15464	SH2 domain-containing adapter protein B	DEG_SPOP_SBC_1	149:153	AASSS	SPOP	0.9824	More...
Q15542	Transcription initiation factor TFIID subunit 5	DEG_SPOP_SBC_1	52:56	AASSS	SPOP	0.9584	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	961:965	AASSS	SPOP	0.9852	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	15:19	AASSS	SPOP	0.8517	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1592:1596	AASSS	SPOP	0.9141	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	1609:1613	AASSS	SPOP	0.9991	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	64:68	AASSS	SPOP	0.9354	More...
Q6ZN18	Zinc finger protein AEBP2	DEG_SPOP_SBC_1	144:148	AASSS	SPOP	0.9629	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1574:1578	AASSS	SPOP	0.9757	More...
Q7Z6L0	Proline-rich transmembrane protein 2	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.9253	More...
Q86UU5	Gametogenetin	DEG_SPOP_SBC_1	257:261	AASSS	SPOP	0.9823	More...
Q86VV8	Rotatin	DEG_SPOP_SBC_1	332:336	AASSS	SPOP	0.9967	More...
Q8NFJ9	Bardet-Biedl syndrome 1 protein	DEG_SPOP_SBC_1	3:7	AASSS	SPOP	0.8652	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	14:18	AASSS	SPOP	0.9962	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1776:1780	AASSS	SPOP	0.9973	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	522:526	AASSS	SPOP	0.9658	More...
Q96DE5	Anaphase-promoting complex subunit 16	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.8429	More...
Q96G42	Kelch domain-containing protein 7B	DEG_SPOP_SBC_1	116:120	AASSS	SPOP	0.8839	More...
Q96JA1	Leucine-rich repeats and immunoglobulin-like domains protein 1	DEG_SPOP_SBC_1	518:522	AASSS	SPOP	0.8568	More...
Q96SF7	T-box transcription factor TBX15	DEG_SPOP_SBC_1	486:490	AASSS	SPOP	0.8965	More...
Q99961	Endophilin-A2	DEG_SPOP_SBC_1	284:288	AASSS	SPOP	0.9979	More...
Q9BYZ6	Rho-related BTB domain-containing protein 2	DEG_SPOP_SBC_1	714:718	AASSS	SPOP	0.8373	More...
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_SPOP_SBC_1	1461:1465	AASSS	SPOP	0.6113	More...
Q9H1R2	Dual specificity protein phosphatase 15	DEG_SPOP_SBC_1	288:292	AASSS	SPOP	0.9533	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	44:48	AASSS	SPOP	0.8189	More...
Q9H7D7	WD repeat-containing protein 26	DEG_SPOP_SBC_1	100:104	AASSS	SPOP	0.5491	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	756:760	AASSS	SPOP	0.9395	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	452:456	AASSS	SPOP	0.9985	More...
Q9HCS4	Transcription factor 7-like 1	DEG_SPOP_SBC_1	528:532	AASSS	SPOP	0.9989	More...
Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.9835	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	83:87	AASSS	SPOP	0.9243	More...
Q9UF56	F-box/LRR-repeat protein 17	DEG_SPOP_SBC_1	93:97	AASSS	SPOP	0.5855	More...
Q9UHC7	E3 ubiquitin-protein ligase makorin-1	DEG_SPOP_SBC_1	129:133	AASSS	SPOP	0.9977	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	456:460	AASSS	SPOP	0.9581	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	DEG_SPOP_SBC_1	762:766	AASSS	SPOP	0.9175	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	942:946	AASSS	SPOP	0.9702	More...
Q13434	Putative E3 ubiquitin-protein ligase makorin-4	DEG_SPOP_SBC_1	164:168	AASSS	SPOP	0.6889	More...
Q66K41	Zinc finger protein 385C	DEG_SPOP_SBC_1	176:180	AASSS	SPOP	0.974	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	247:251	AASSS	SPOP	0.9823	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	757:761	AASSS	SPOP	0.9809	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	169:173	AASSS	SPOP	0.9418	More...
Q09019	Dystrophia myotonica WD repeat-containing protein	DEG_SPOP_SBC_1	472:476	AASSS	SPOP	0.541	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	1084:1088	AASSS	SPOP	0.9765	More...
Q6UWI4	Protein shisa-2 homolog	DEG_SPOP_SBC_1	184:188	AASSS	SPOP	0.9934	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	738:742	AASSS	SPOP	0.991	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	96:100	AASSS	SPOP	0.9824	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	125:129	AASSS	SPOP	0.9934	More...
Q7Z5M5	Transmembrane channel-like protein 3	DEG_SPOP_SBC_1	1046:1050	AASSS	SPOP	0.9343	More...
Q86XZ4	Spermatogenesis-associated serine-rich protein 2	DEG_SPOP_SBC_1	400:404	AASSS	SPOP	0.9733	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	151:155	AASSS	SPOP	0.9574	More...
Q9Y2H5	Pleckstrin homology domain-containing family A member 6	DEG_SPOP_SBC_1	439:443	AASSS	SPOP	0.5059	More...
Q5BKY9	Protein FAM133B	DEG_SPOP_SBC_1	239:243	AASSS	SPOP	0.7438	More...
Q6P1R3	Myb/SANT-like DNA-binding domain-containing protein 2	DEG_SPOP_SBC_1	75:79	AASSS	SPOP	0.9629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASSS

Degron related mutations and impact score

Drug responses associated with AR mutations

All proteins holding degron of AASSS