DegronMD - P56975(NRG3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P508S	TCGA-05-4398	LUAD	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.G503V	TCGA-05-5425	LUAD	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6421
p.S204R	TCGA-34-2609	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.S204R	TCGA-DD-A4NF	LIHC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.S204R	DO44950	LIHC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.S204R	DO26981	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.T277M	TCGA-55-8506	LUAD	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.R493M	TCGA-A5-A0GH	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1944
p.S500R	TCGA-A5-A1OF	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6316
p.E514K	TCGA-AG-3878	READ	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.E514K	TCGA-BT-A20T	BLCA	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.E514K	TCGA-VQ-A8PH	STAD	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.E514K	ACH-002508	Skin Cancer	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.H275Y	TCGA-AG-A002	READ	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H275Y	TCGA-B5-A0JY	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H275Y	TCGA-F5-6814	READ	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H275Y	DO8898	COAD	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H275Y	DO233169	GACA	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H275Y	DO36556	READ	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H275Y	DO43041	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.A188V	TCGA-AJ-A3EL	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.A188V	TCGA-E6-A1LX	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.A188V	DO41020	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.A188V	DO41542	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.T276M	TCGA-AP-A051	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.T276M	TCGA-BR-8680	STAD	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.A261T	TCGA-AP-A056	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.A261T	TCGA-AP-A056	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.A261T	DO43971	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.A261T	DO43971	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.E515D	TCGA-AP-A1E0	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.0833
p.P199L	TCGA-AX-A1CE	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.P199L	DO42280	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.P496L	TCGA-B5-A3FA	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.P496L	ACH-001736	Leukemia	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.R185W	TCGA-BR-4184	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.R185W	DO38328	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.L502V	TCGA-C8-A1HM	BRCA	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6765
p.T205M	TCGA-CM-5348	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.T205M	TCGA-JY-A6F8	ESCA	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.T205M	DO9514	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.S271G	TCGA-D5-6927	COAD	TCGA	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.S271G	DO10332	COAD	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.S203C	TCGA-D6-A4Z9	HNSC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.S203C	DO44419	HNSC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.R499Q	TCGA-IR-A3LA	CESC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7329
p.S238P	TCGA-MH-A55W	KIRP	TCGA	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.1667
p.S238P	DO48516	KIRP	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.1667
p.A189S	TCGA-NC-A5HI	LUSC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2222
p.A189S	DO45461	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2222
p.G503A	TCGA-NC-A5HM	LUSC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6429
p.A509P	TCGA-T2-A6WZ	HNSC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.25
p.A191S	TCGA-T3-A92N	HNSC	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191S	DO219073	HNSC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A251T	TCGA-VQ-A8P2	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6028
p.A251T	DO51761	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6028
p.A191V	TCGA-VQ-A927	STAD	TCGA	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191V	DO234415	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191V	DO51797	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.R278Q	DO44377	CESC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.R278Q	DO234374	ESAD	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.R278Q	DO223130	ESCA	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.L186P	DO223359	CLLE	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.L186P	DO222755	COCA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.L186P	DO49418	PACA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.L186P	DO38591	STAD	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.D494Y	DO8264	COAD	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2222
p.D237N	DO222884	COCA	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.1389
p.T197M	DO234230	ESAD	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.7423
p.R261K	DO234395	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.R261K	DO234395	ESAD	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.N186K	DO233270	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.T192M	DO233202	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.W242S	DO233730	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.W242S	DO233730	GACA	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.2778
p.A198S	DO233747	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.A198S	DO229029	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.A198S	DO229026	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.K200N	DO233864	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.R493K	DO15623	HNSC	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1944
p.G259V	DO20786	KIRP	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.G259V	DO20786	KIRP	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.G259V	DO20786	KIRP	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.P234S	DO228589	LICA	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.A188S	DO228976	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.V199L	DO229019	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.G207V	DO229031	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.G263C	DO229036	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0833
p.G263C	DO229036	LICA	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.25
p.K194N	DO229045	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.6918
p.P237S	DO231797	LINC	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.1389
p.P190T	DO23410	LINC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.R185Q	DO229177	LMS	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.R185Q	SIDM01439	Hepatocellular Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.R185Q	ACH-000537	Liver Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.R261T	DO25508	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.R261T	DO25508	LUAD	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.H248Y	DO25153	LUAD	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation altering degron motif	0.7229
p.C255S	DO231155	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation blocking phosphorylation signal	0.75
p.C255S	DO231155	LUSC	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation blocking phosphorylation signal	0.6111
p.M192I	DO45425	LUSC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.P275L	DO220877	MELA	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.P275L	DO52402	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.P275S	DO220877	MELA	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.E490K	DO222647	MELA	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.E490K	DO38051	SKCM	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.E490K	DO51298	SKCM	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.S259F	DO222702	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.S259F	DO222702	MELA	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.S259F	DO222702	MELA	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.L205Q	DO228797	PBCA	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.S245P	DO232761	PBCA	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation altering degron motif	0.5641
p.G259R	DO51301	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.G259R	DO51301	SKCM	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.G259R	DO51301	SKCM	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.P237T	DO219464	SKCM	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.1389
p.S495Y	DO47769	STAD	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.25
p.A188T	DO42023	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.R272M	DO43634	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.2778
p.P258T	DO41584	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.P258T	DO41584	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.P258T	DO41584	UCEC	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0833
p.L265F	DO41542	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.R261I	DO52426	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.R261I	DO52426	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.S279R	DO42568	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0833
p.S245Y	DO41133	UCEC	ICGC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation altering degron motif	0.6009
p.S253F	SIDM00545	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7982
p.S253F	ACH-000987	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7982
p.S203G	SIDM00491	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.S203G	ACH-001443	Thyroid Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.S203G	ASH-3	thyroid	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.G504E	SIDM01175	Other Sarcomas	GDSC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6087
p.G504E	ACH-002309	Sarcoma	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6087
p.G504E	SW684	soft tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.6087
p.G507V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.G507V	ACH-000718	Lung Cancer	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.G507V	NCI-H2291	lung	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.3056
p.T262A	SIDM00211	B-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.T262A	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.2222
p.A191T	SIDM00596	Endometrial Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191T	ACH-000941	Endometrial/Uterine Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191T	ACH-000954	Endometrial/Uterine Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191T	ACH-001517	Endometrial/Uterine Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A191T	HEC-1	endometrium	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.P194S	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.5641
p.P194S	ACH-000334	Lymphoma	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.5641
p.P194S	DB	haematopoietic and lymphoid tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.5641
p.A189D	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2222
p.A189D	ACH-000627	Lung Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2222
p.A189D	LCLC-103H	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2222
p.P199T	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.P199T	ACH-000553	Lung Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.G254R	NCI-H1792	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7568
p.G254R	NCI-H522	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7568
p.V259F	SNG-M	endometrium	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.V259F	SNG-M	endometrium	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.V259F	SNG-M	endometrium	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.G280R	NCI-H522	lung	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.G280R	NCI-H1792	lung	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.Q190K	LOUCY	haematopoietic and lymphoid tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.S207R	NCI-H520	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.D258E	NCI-H1581	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.D258E	NCI-H1581	lung	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.D258E	NCI-H1581	lung	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0833
p.R241K	K2	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0833
p.R241K	K2	skin	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.25
p.P197H	NCI-H1573	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.7694
p.P259H	HMV-II	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.P259H	HMV-II	skin	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.P259H	HMV-II	skin	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.R266K	K2	skin	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7237
p.V191M	NCI-H358	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.K207N	NCI-H226	lung	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.P240S	MRK-nu-1	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0556
p.P240S	MRK-nu-1	breast	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.2222
p.E185D	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.A244T	OC-314	ovary	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation altering degron motif	0.7139
p.K278E	MFE-296	endometrium	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.P234H	HMV-II	skin	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.V259I	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.V259I	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.V259I	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.0556
p.S190I	SNU-1040	large intestine	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.S241I	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.0833
p.S241I	SNU-1040	large intestine	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation rewiring degron network	0.25
p.N489D	MN-60	haematopoietic and lymphoid tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.0833
p.A193T	OC-314	ovary	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.7139
p.P255L	KYSE-510	oesophagus	COSMIC	AASSS	DEG_SPOP_SBC_1	250:254	Mutation blocking phosphorylation signal	0.75
p.P255L	KYSE-510	oesophagus	COSMIC	LSPFQD	LIG_APCC_ABBA_1	244:249	Mutation blocking phosphorylation signal	0.6111
p.P266S	MRK-nu-1	breast	COSMIC	PETST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.6752
p.N490D	MN-60	haematopoietic and lymphoid tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1111
p.L200P	HCT-116	large intestine	COSMIC	VPSTT	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.R508Q	CMK	haematopoietic and lymphoid tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.2778
p.N516D	MN-60	haematopoietic and lymphoid tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRG3

UniProt ID: P56975

Entrez ID: 10718

Protein name: Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) [Cleaved into: Neuregulin-3 (NRG-3)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRG3 in