DegronMD

Uniprot ID: P56975

Source protein: Pro-neuregulin-3, membrane-bound isoform

Source gene: NRG3

Class: DEG_SPOP_SBC_1

Location: 266:270

E3 ligase: SPOP

DEGRON score: 0.5927

ASA_SCORE: 87.06

COIL: 0.8628

CONS_SCORE: 0.4644

DSS_SCORE: 0.5652

HELIX: 0.032

FCONS_SCORE: 1.1015

RIG_SCORE: 0.5747

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T277M	TCGA-55-8506	LUAD	TCGA	PETST	DEG_SPOP_SBC_1	0.1389
p.H275Y	TCGA-AG-A002	READ	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.H275Y	TCGA-B5-A0JY	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.H275Y	TCGA-F5-6814	READ	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.H275Y	DO8898	COAD	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.H275Y	DO233169	GACA	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.H275Y	DO36556	READ	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.H275Y	DO43041	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.T276M	TCGA-AP-A051	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.1667
p.T276M	TCGA-BR-8680	STAD	TCGA	PETST	DEG_SPOP_SBC_1	0.1667
p.A261T	TCGA-AP-A056	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.A261T	DO43971	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.S271G	TCGA-D5-6927	COAD	TCGA	PETST	DEG_SPOP_SBC_1	0.3056
p.S271G	DO10332	COAD	ICGC	PETST	DEG_SPOP_SBC_1	0.3056
p.R278Q	DO44377	CESC	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.R278Q	DO234374	ESAD	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.R278Q	DO223130	ESCA	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.R261K	DO234395	ESAD	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.G259V	DO20786	KIRP	ICGC	PETST	DEG_SPOP_SBC_1	0.1389
p.G263C	DO229036	LICA	ICGC	PETST	DEG_SPOP_SBC_1	0.25
p.R261T	DO25508	LUAD	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.P275L	DO220877	MELA	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.P275L	DO52402	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.P275S	DO220877	MELA	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.S259F	DO222702	MELA	ICGC	PETST	DEG_SPOP_SBC_1	0.1389
p.G259R	DO51301	SKCM	ICGC	PETST	DEG_SPOP_SBC_1	0.1389
p.R272M	DO43634	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.2778
p.P258T	DO41584	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.L265F	DO41542	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.3056
p.R261I	DO52426	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.S279R	DO42568	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.0833
p.T262A	SIDM00211	B-Lymphoblastic Leukemia	GDSC	PETST	DEG_SPOP_SBC_1	0.2222
p.V259F	SNG-M	endometrium	COSMIC	PETST	DEG_SPOP_SBC_1	0.1389
p.G280R	NCI-H522	lung	COSMIC	PETST	DEG_SPOP_SBC_1	0.0556
p.G280R	NCI-H1792	lung	COSMIC	PETST	DEG_SPOP_SBC_1	0.0556
p.D258E	NCI-H1581	lung	COSMIC	PETST	DEG_SPOP_SBC_1	0.1111
p.P259H	HMV-II	skin	COSMIC	PETST	DEG_SPOP_SBC_1	0.1389
p.R266K	K2	skin	COSMIC	PETST	DEG_SPOP_SBC_1	0.7237
p.K278E	MFE-296	endometrium	COSMIC	PETST	DEG_SPOP_SBC_1	0.1111
p.V259I	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	PETST	DEG_SPOP_SBC_1	0.1389
p.P266S	MRK-nu-1	breast	COSMIC	PETST	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	355:359	PETST	SPOP	0.986	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	266:270	PETST	SPOP	0.5927	More...
Q5BJH2	Transmembrane protein 128	DEG_SPOP_SBC_1	32:36	PETST	SPOP	0.8321	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8176:8180	PETST	SPOP	0.5974	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1235:1239	PETST	SPOP	0.6169	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	399:403	PETST	SPOP	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETST

Degron related mutations and impact score

Drug responses associated with NRG3 mutations

All proteins holding degron of PETST