DegronMD

Uniprot ID: Q5BJH2

Source protein: Transmembrane protein 128

Source gene: TMEM128

Class: DEG_SPOP_SBC_1

Location: 32:36

E3 ligase: SPOP

DEGRON score: 0.8321

ASA_SCORE: 92.74

COIL: 0.7472

CONS_SCORE: 0.3679

DSS_SCORE: 0.6603

HELIX: 0.2386

FCONS_SCORE: 1.0649

RIG_SCORE: 0.6578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L24R	TCGA-DD-A3A8	LIHC	TCGA	PETST	DEG_SPOP_SBC_1	0.1111
p.V37F	TCGA-DD-AACT	LIHC	TCGA	PETST	DEG_SPOP_SBC_1	0.3056
p.H27Y	TCGA-EE-A29R	SKCM	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.A34T	TCGA-EO-A3AZ	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.7139
p.K43E	DO223732	CESC	ICGC	PETST	DEG_SPOP_SBC_1	0.25
p.V38F	DO234152	ESAD	ICGC	PETST	DEG_SPOP_SBC_1	0.2778
p.D29E	DO229027	LICA	ICGC	PETST	DEG_SPOP_SBC_1	0.25
p.K43T	DO47769	STAD	ICGC	PETST	DEG_SPOP_SBC_1	0.25
p.A30S	DO229272	THCA	ICGC	PETST	DEG_SPOP_SBC_1	0.2778
p.K40Q	DO43306	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.3333
p.P32L	ACH-001528	Thyroid Cancer	CCLE	PETST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	355:359	PETST	SPOP	0.986	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	266:270	PETST	SPOP	0.5927	More...
Q5BJH2	Transmembrane protein 128	DEG_SPOP_SBC_1	32:36	PETST	SPOP	0.8321	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8176:8180	PETST	SPOP	0.5974	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1235:1239	PETST	SPOP	0.6169	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	399:403	PETST	SPOP	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons