DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8176:8180

E3 ligase: SPOP

DEGRON score: 0.5974

ASA_SCORE: 93.4

COIL: 0.88

CONS_SCORE: 0

DSS_SCORE: 0.5429

HELIX: 0.0208

FCONS_SCORE: 0

RIG_SCORE: 0.7048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L8172I	TCGA-05-4249	LUAD	TCGA	PETST	DEG_SPOP_SBC_1	0.2222
p.L8172I	DO23891	LUAD	ICGC	PETST	DEG_SPOP_SBC_1	0.2222
p.V8174M	TCGA-12-3650	GBM	TCGA	PETST	DEG_SPOP_SBC_1	0.2778
p.V8174M	DO12172	GBM	ICGC	PETST	DEG_SPOP_SBC_1	0.2778
p.S8175P	TCGA-AA-A010	COAD	TCGA	PETST	DEG_SPOP_SBC_1	0.3056
p.S8189P	TCGA-B5-A11S	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.0833
p.S8189P	DO41895	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.0833
p.T8188I	TCGA-BP-5004	KIRC	TCGA	PETST	DEG_SPOP_SBC_1	0.1111
p.T8188I	DO17353	KIRC	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.S8175L	TCGA-C5-A3HF	CESC	TCGA	PETST	DEG_SPOP_SBC_1	0.3056
p.S8175L	TCGA-Z2-A8RT	SKCM	TCGA	PETST	DEG_SPOP_SBC_1	0.3056
p.S8175L	DO49015	CESC	ICGC	PETST	DEG_SPOP_SBC_1	0.3056
p.S8175L	DO51301	SKCM	ICGC	PETST	DEG_SPOP_SBC_1	0.3056
p.S8190G	TCGA-D7-6818	STAD	TCGA	PETST	DEG_SPOP_SBC_1	0.0556
p.S8190G	DO38262	STAD	ICGC	PETST	DEG_SPOP_SBC_1	0.0556
p.S8179F	TCGA-EE-A29D	SKCM	TCGA	PETST	DEG_SPOP_SBC_1	0.7982
p.S8179F	DO220899	MELA	ICGC	PETST	DEG_SPOP_SBC_1	0.7982
p.S8179F	DO222527	MELA	ICGC	PETST	DEG_SPOP_SBC_1	0.7982
p.S8179F	DO38123	SKCM	ICGC	PETST	DEG_SPOP_SBC_1	0.7982
p.R8185K	TCGA-EO-A3B0	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.R8185K	DO219773	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.E8181K	TCGA-F5-6814	READ	TCGA	PETST	DEG_SPOP_SBC_1	0.3056
p.E8181K	DO36556	READ	ICGC	PETST	DEG_SPOP_SBC_1	0.3056
p.A8170S	DO48296	ESCA	ICGC	PETST	DEG_SPOP_SBC_1	0.1667
p.S8190R	DO222444	ESCA	ICGC	PETST	DEG_SPOP_SBC_1	0.0556
p.S8190R	DO229253	THCA	ICGC	PETST	DEG_SPOP_SBC_1	0.0556
p.P8176S	DO228196	LICA	ICGC	PETST	DEG_SPOP_SBC_1	0.6752
p.I8166V	DO32980	PACA	ICGC	PETST	DEG_SPOP_SBC_1	0.0556
p.Q8171H	ACH-000941	Endometrial/Uterine Cancer	CCLE	PETST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	355:359	PETST	SPOP	0.986	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	266:270	PETST	SPOP	0.5927	More...
Q5BJH2	Transmembrane protein 128	DEG_SPOP_SBC_1	32:36	PETST	SPOP	0.8321	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8176:8180	PETST	SPOP	0.5974	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1235:1239	PETST	SPOP	0.6169	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	399:403	PETST	SPOP	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PETST