DegronMD

Uniprot ID: Q9Y572

Source protein: Receptor-interacting serine/threonine-protein kinase 3

Source gene: RIPK3

Class: DEG_SPOP_SBC_1

Location: 399:403

E3 ligase: SPOP

DEGRON score: 0.9132

ASA_SCORE: 91.28

COIL: 0.886

CONS_SCORE: 0.3115

DSS_SCORE: 0.8727

HELIX: 0.0794

FCONS_SCORE: 0.9879

RIG_SCORE: 0.6167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S391L	TCGA-AA-A00N	COAD	TCGA	PETST	DEG_SPOP_SBC_1	0.1111
p.S391L	DO9876	COAD	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.S391L	SIDM01276	Colorectal Carcinoma	GDSC	PETST	DEG_SPOP_SBC_1	0.1111
p.P409S	TCGA-CK-4951	COAD	TCGA	PETST	DEG_SPOP_SBC_1	0.1667
p.P409S	DO10582	COAD	ICGC	PETST	DEG_SPOP_SBC_1	0.1667
p.P409H	TCGA-D3-A2J6	SKCM	TCGA	PETST	DEG_SPOP_SBC_1	0.1667
p.P409H	DO37901	SKCM	ICGC	PETST	DEG_SPOP_SBC_1	0.1667
p.P411S	TCGA-EE-A29L	SKCM	TCGA	PETST	DEG_SPOP_SBC_1	0.1111
p.P411S	DO222599	MELA	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.P411S	DO37835	SKCM	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.D390Y	TCGA-FI-A2D0	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.0833
p.D390Y	DO43891	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.0833
p.A393D	DO228952	LICA	ICGC	PETST	DEG_SPOP_SBC_1	0.1667
p.S410R	DO229036	LICA	ICGC	PETST	DEG_SPOP_SBC_1	0.5833
p.T403A	SIDM01711	Non-Cancerous	GDSC	PETST	DEG_SPOP_SBC_1	0.7139
p.T403A	ACH-002350	Non-Cancerous	CCLE	PETST	DEG_SPOP_SBC_1	0.7139
p.T403P	SIDM00368	Small Cell Lung Carcinoma	GDSC	PETST	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	355:359	PETST	SPOP	0.986	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	266:270	PETST	SPOP	0.5927	More...
Q5BJH2	Transmembrane protein 128	DEG_SPOP_SBC_1	32:36	PETST	SPOP	0.8321	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8176:8180	PETST	SPOP	0.5974	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1235:1239	PETST	SPOP	0.6169	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	399:403	PETST	SPOP	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons