DegronMD

Uniprot ID: Q9NR48

Source protein: Histone-lysine N-methyltransferase ASH1L

Source gene: ASH1L

Class: DEG_SPOP_SBC_1

Location: 1235:1239

E3 ligase: SPOP

DEGRON score: 0.6169

ASA_SCORE: 85.34

COIL: 0.78

CONS_SCORE: 0.367

DSS_SCORE: 0.4852

HELIX: 0.1932

FCONS_SCORE: 0.9119

RIG_SCORE: 0.6985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1227S	TCGA-25-1326	OV	TCGA	PETST	DEG_SPOP_SBC_1	0.1111
p.F1227S	DO28154	OV	ICGC	PETST	DEG_SPOP_SBC_1	0.1111
p.H1225Y	TCGA-A7-A26F	BRCA	TCGA	PETST	DEG_SPOP_SBC_1	0.0556
p.H1225Y	DO1732	BRCA	ICGC	PETST	DEG_SPOP_SBC_1	0.0556
p.S1226Y	TCGA-AN-A046	BRCA	TCGA	PETST	DEG_SPOP_SBC_1	0.5278
p.S1226Y	DO1285	BRCA	ICGC	PETST	DEG_SPOP_SBC_1	0.5278
p.E1246Q	DO222867	BTCA	ICGC	PETST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	355:359	PETST	SPOP	0.986	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	266:270	PETST	SPOP	0.5927	More...
Q5BJH2	Transmembrane protein 128	DEG_SPOP_SBC_1	32:36	PETST	SPOP	0.8321	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8176:8180	PETST	SPOP	0.5974	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1235:1239	PETST	SPOP	0.6169	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	399:403	PETST	SPOP	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons