DegronMD - P54132(BLM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q184L	TCGA-60-2711	LUSC	TCGA	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.0833
p.Q184L	DO26987	LUSC	ICGC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.0833
p.S175I	TCGA-63-A5MB	LUSC	TCGA	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation altering degron motif	0.8453
p.S175I	DO52018	LUSC	ICGC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation altering degron motif	0.8453
p.S304Y	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation blocking phosphorylation signal	0.5833
p.S304Y	DO41235	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation blocking phosphorylation signal	0.5833
p.Q184E	TCGA-AC-A23H	BRCA	TCGA	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.0833
p.Q184E	DO2401	BRCA	ICGC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.0833
p.M350I	TCGA-AP-A059	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1944
p.M350I	DO41361	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1944
p.L600F	TCGA-AP-A059	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.0833
p.L600F	DO41361	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.0833
p.D340Y	TCGA-AP-A0LM	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2778
p.D340Y	DO229257	THCA	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2778
p.D340Y	DO43306	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2778
p.V334I	TCGA-AX-A0J1	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7076
p.V334I	DO41199	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7076
p.K535Q	TCGA-B0-5710	KIRC	TCGA	VLTST	DEG_SPOP_SBC_1	524:528	Mutation blocking ubiquitination signal	0.5833
p.K535Q	DO16308	KIRC	ICGC	VLTST	DEG_SPOP_SBC_1	524:528	Mutation blocking ubiquitination signal	0.5833
p.R179I	TCGA-DD-AADO	LIHC	TCGA	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.2222
p.R179I	DO52241	LIHC	ICGC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.2222
p.L335F	TCGA-FR-A726	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.587
p.L335F	DO48665	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.587
p.S310C	TCGA-JW-A5VL	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.S310C	DO49976	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.3056
p.M348I	TCGA-UC-A7PG	CESC	TCGA	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348I	TCGA-UC-A7PG	CESC	TCGA	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348I	DO51615	CESC	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348I	DO51615	CESC	ICGC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348I	DO229005	COCA	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348I	DO229005	COCA	ICGC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348I	SIDM00588	Oral Cavity Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348I	SIDM00588	Oral Cavity Carcinoma	GDSC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348I	SIDM01447	Glioblastoma	GDSC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348I	SIDM01447	Glioblastoma	GDSC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348I	HSC-4	upper aerodigestive tract	COSMIC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348I	HSC-4	upper aerodigestive tract	COSMIC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348V	TCGA-Y8-A894	KIRP	TCGA	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348V	TCGA-Y8-A894	KIRP	TCGA	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.M348V	DO49798	KIRP	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0556
p.M348V	DO49798	KIRP	ICGC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.S328C	TCGA-ZF-AA54	BLCA	TCGA	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation blocking phosphorylation signal	0.6111
p.S328C	DO219098	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation blocking phosphorylation signal	0.6111
p.T526P	DO48413	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	524:528	Mutation altering degron motif	0.7031
p.E346K	DO223035	ESCA	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.E346K	DO223035	ESCA	ICGC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0833
p.Q365L	DO228217	LICA	ICGC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1667
p.D161Y	DO229018	LICA	ICGC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.0833
p.Q184H	DO229015	LICA	ICGC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.0833
p.S336I	DO229036	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7341
p.V334F	DO229045	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7068
p.Y519C	DO44788	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	524:528	Mutation rewiring degron network	0.1944
p.S601Y	DO52653	MALY	ICGC	PVSST	DEG_SPOP_SBC_1	609:613	Mutation blocking phosphorylation signal	0.5556
p.V530E	DO218900	SKCA	ICGC	VLTST	DEG_SPOP_SBC_1	524:528	Mutation rewiring degron network	0.2778
p.C318S	SIDM00216	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.25
p.C318S	ACH-000989	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.25
p.C318S	SNU-175	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.25
p.K323R	SIDM01483	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation blocking ubiquitination signal	0.5556
p.K323R	SIDM01240	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation blocking ubiquitination signal	0.5556
p.E307G	SIDM00932	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.2222
p.E307G	ACH-000457	Kidney Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.2222
p.E307G	CAL-54	kidney	COSMIC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.2222
p.A603V	SIDM00282	Colorectal Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.A603V	ACH-000998	Colon/Colorectal Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.A603V	CW-2	large intestine	COSMIC	PVSST	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.D329H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.D329H	ACH-000995	Leukemia	CCLE	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.D329H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.I366T	SIDM01113	Other Sarcomas	GDSC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.I366T	SK-UT-1	soft tissue	COSMIC	PETST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389
p.K347N	SIDM00118	Colorectal Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation substituting flanking lysine	0.1944
p.K347N	SIDM00118	Colorectal Carcinoma	GDSC	PETST	DEG_SPOP_SBC_1	355:359	Mutation substituting flanking lysine	0.2222
p.K347N	ACH-001081	Colon/Colorectal Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation substituting flanking lysine	0.1944
p.K347N	ACH-001081	Colon/Colorectal Cancer	CCLE	PETST	DEG_SPOP_SBC_1	355:359	Mutation substituting flanking lysine	0.2222
p.K347N	HCC2998	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	334:338	Mutation substituting flanking lysine	0.1944
p.K347N	HCC2998	large intestine	COSMIC	PETST	DEG_SPOP_SBC_1	355:359	Mutation substituting flanking lysine	0.2222
p.I309F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.2778
p.I309F	ACH-000964	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.2778
p.T162I	SIDM01617	Endometrial Carcinoma	GDSC	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.1111
p.T162I	ACH-000994	Endometrial/Uterine Cancer	CCLE	VTPPQS	DEG_SCF_FBW7_1	170:175	Mutation rewiring degron network	0.1111

Kaplan plot for BLM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BLM

UniProt ID: P54132

Entrez ID: 641

Protein name: Bloom syndrome protein (EC 3.6.4.12) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BLM in