DegronMD

Uniprot ID: P54132

Source protein: Bloom syndrome protein

Source gene: BLM

Class: DEG_SPOP_SBC_1

Location: 524:528

E3 ligase: SPOP

DEGRON score: 0.9878

ASA_SCORE: 66.4

COIL: 0.7358

CONS_SCORE: 0.202

DSS_SCORE: 0.4614

HELIX: 0.0954

FCONS_SCORE: 0.9429

RIG_SCORE: 0.7424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K535Q	TCGA-B0-5710	KIRC	TCGA	VLTST	DEG_SPOP_SBC_1	0.5833
p.K535Q	DO16308	KIRC	ICGC	VLTST	DEG_SPOP_SBC_1	0.5833
p.T526P	DO48413	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.Y519C	DO44788	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	0.1944
p.V530E	DO218900	SKCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons