DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_SPOP_SBC_1

Location: 1471:1475

E3 ligase: SPOP

DEGRON score: 0.9481

ASA_SCORE: 85.24

COIL: 0.7988

CONS_SCORE: 0.5381

DSS_SCORE: 0.5404

HELIX: 0.0376

FCONS_SCORE: 1.4788

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1472F	TCGA-61-1904	OV	TCGA	VLTST	DEG_SPOP_SBC_1	0.587
p.L1472F	DO28077	OV	ICGC	VLTST	DEG_SPOP_SBC_1	0.587
p.S1484F	TCGA-AP-A1DK	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.0833
p.S1484F	DO42033	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.0833
p.L1462F	TCGA-CV-7568	HNSC	TCGA	VLTST	DEG_SPOP_SBC_1	0.0833
p.L1462F	DO14160	HNSC	ICGC	VLTST	DEG_SPOP_SBC_1	0.0833
p.P1467Q	DO228948	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons