DegronMD

Uniprot ID: Q9H4G0

Source protein: Band 4.1-like protein 1

Source gene: EPB41L1

Class: DEG_SPOP_SBC_1

Location: 791:795

E3 ligase: SPOP

DEGRON score: 0.6823

ASA_SCORE: 66.58

COIL: 0.5296

CONS_SCORE: 0.581

DSS_SCORE: 0.3087

HELIX: 0.049

FCONS_SCORE: 0.9424

RIG_SCORE: 0.8104

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T799N	TCGA-AB-2808	LAML	TCGA	VLTST	DEG_SPOP_SBC_1	0.6667
p.G797S	TCGA-AZ-4615	COAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.2778
p.G797S	TCGA-BF-AAP2	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.2778
p.S782F	TCGA-BS-A0UV	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.5278
p.S782F	DO42793	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.5278
p.R781S	TCGA-EE-A29Q	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.0556
p.G796S	DO7977	COAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.75
p.G796S	DO219466	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.75
p.T798N	DO21487	LAML	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.G788R	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.25
p.G788R	ACH-002393	Lymphoma	CCLE	VLTST	DEG_SPOP_SBC_1	0.25
p.G788R	CRO-AP3	NS	COSMIC	VLTST	DEG_SPOP_SBC_1	0.25
p.R781H	ACH-001664	Gastric Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.0556
p.G787R	CRO-AP3	NS	COSMIC	VLTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons