DegronMD

Uniprot ID: Q9H8V3

Source protein: Protein ECT2

Source gene: ECT2

Class: DEG_SPOP_SBC_1

Location: 6:10

E3 ligase: SPOP

DEGRON score: 0.9236

ASA_SCORE: 59.54

COIL: 0.473

CONS_SCORE: 0.336

DSS_SCORE: 0.5847

HELIX: 0.0272

FCONS_SCORE: 1.2042

RIG_SCORE: 0.7387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S19C	TCGA-BT-A42C	BLCA	TCGA	VLTST	DEG_SPOP_SBC_1	0.5278
p.S19C	DO49725	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.5278
p.S15T	SIDM00915	Small Cell Lung Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.6389
p.S15T	SIDM01039	Other Solid Cancers	GDSC	VLTST	DEG_SPOP_SBC_1	0.6389
p.S15T	SIDM00875	Breast Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.6389
p.S15T	SIDM00032	Bladder Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.6389
p.S15T	SIDM01409	Bladder Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons