DegronMD - Q9H8V3(ECT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S420A	TCGA-63-A5MW	LUSC	TCGA	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7588
p.S420F	TCGA-63-A5MW	LUSC	TCGA	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7982
p.S412F	TCGA-AC-A23H	BRCA	TCGA	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.5833
p.S19C	TCGA-BT-A42C	BLCA	TCGA	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.5278
p.S19C	DO49725	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.5278
p.G414V	TCGA-D3-A2JP	SKCM	TCGA	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1944
p.S435C	TCGA-IR-A3LH	CESC	TCGA	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0833
p.E432G	DO225238	BRCA	ICGC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667
p.A420S	DO228974	LICA	ICGC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7588
p.T412I	DO38539	STAD	ICGC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.5833
p.S15T	SIDM00915	Small Cell Lung Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.6389
p.S15T	SIDM01039	Other Solid Cancers	GDSC	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.6389
p.S15T	SIDM00875	Breast Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.6389
p.S15T	SIDM00032	Bladder Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.6389
p.S15T	SIDM01409	Bladder Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	6:10	Mutation blocking phosphorylation signal	0.6389
p.L416P	SIDM00596	Endometrial Carcinoma	GDSC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.25
p.L416P	HEC-1	endometrium	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.25
p.I413V	SIDM00365	Small Cell Lung Carcinoma	GDSC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667
p.I413V	SBC-1	lung	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667
p.P414A	ACH-002215	Lymphoma	CCLE	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1944
p.P414A	BC-3	haematopoietic and lymphoid tissue	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1944
p.P413A	BC-3	haematopoietic and lymphoid tissue	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667

Kaplan plot for ECT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ECT2

UniProt ID: Q9H8V3

Entrez ID: 1894

Protein name: Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ECT2 in