DegronMD

Uniprot ID: Q9H8V3

Source protein: Protein ECT2

Source gene: ECT2

Class: DEG_SCF_FBW7_1

Location: 419:426

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 61.5875

COIL: 0.7654

CONS_SCORE: 0.4334

DSS_SCORE: 0.5078

HELIX: 0.1584

FCONS_SCORE: 1.0188

RIG_SCORE: 0.6543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S420A	TCGA-63-A5MW	LUSC	TCGA	ISNTPESS	DEG_SCF_FBW7_1	0.7588
p.S420F	TCGA-63-A5MW	LUSC	TCGA	ISNTPESS	DEG_SCF_FBW7_1	0.7982
p.S412F	TCGA-AC-A23H	BRCA	TCGA	ISNTPESS	DEG_SCF_FBW7_1	0.5833
p.G414V	TCGA-D3-A2JP	SKCM	TCGA	ISNTPESS	DEG_SCF_FBW7_1	0.1944
p.S435C	TCGA-IR-A3LH	CESC	TCGA	ISNTPESS	DEG_SCF_FBW7_1	0.0833
p.E432G	DO225238	BRCA	ICGC	ISNTPESS	DEG_SCF_FBW7_1	0.1667
p.A420S	DO228974	LICA	ICGC	ISNTPESS	DEG_SCF_FBW7_1	0.7588
p.T412I	DO38539	STAD	ICGC	ISNTPESS	DEG_SCF_FBW7_1	0.5833
p.L416P	SIDM00596	Endometrial Carcinoma	GDSC	ISNTPESS	DEG_SCF_FBW7_1	0.25
p.L416P	HEC-1	endometrium	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	0.25
p.I413V	SIDM00365	Small Cell Lung Carcinoma	GDSC	ISNTPESS	DEG_SCF_FBW7_1	0.1667
p.I413V	SBC-1	lung	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	0.1667
p.P414A	ACH-002215	Lymphoma	CCLE	ISNTPESS	DEG_SCF_FBW7_1	0.1944
p.P414A	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	0.1944
p.P413A	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	ISNTPESS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8V3	Protein ECT2	DEG_SCF_FBW7_1	419:426	ISNTPESS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons