DegronMD

Uniprot ID: Q5T8D3

Source protein: Acyl-CoA-binding domain-containing protein 5

Source gene: ACBD5

Class: DEG_SPOP_SBC_1

Location: 177:181

E3 ligase: SPOP

DEGRON score: 0.998

ASA_SCORE: 70.7

COIL: 0.7256

CONS_SCORE: 0.475

DSS_SCORE: 0.4354

HELIX: 0.1202

FCONS_SCORE: 1.0361

RIG_SCORE: 0.7348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N174I	TCGA-17-Z017	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.25
p.V178F	TCGA-44-7661	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.7068
p.E190K	TCGA-AX-A1CE	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.1944
p.E190K	TCGA-AX-A2HC	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.1944
p.P182T	DO225346	BRCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.3056
p.S180Y	DO229036	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	0.712
p.V187F	DO23602	LUAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.1667
p.E191G	COLO-829	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.0556
p.D183N	LOXIMVI	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.2778
p.N170S	22RV1	prostate	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons