DegronMD - Q9H4G0(EPB41L1)

FUNCTION: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.

GO - Biological processes (BP): actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]

GO - Molecular function (MF): actin binding [GO:0003779]; structural molecule activity [GO:0005198]

GO - Cellular component (CC): cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S745F	DO223907	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation altering degron motif	0.7982
p.G796S	DO7977	COAD	ICGC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.75
p.G796S	DO219466	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.75
p.R864K	DO51246	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.7237
p.T613A	TCGA-BT-A20J	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7139
p.T613A	DO457	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7139
p.V861F	DO228918	LICA	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.7068
p.S746F	TCGA-BF-AAOX	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation altering degron motif	0.6871
p.T799N	TCGA-AB-2808	LAML	TCGA	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.6667
p.S870F	SIDM00973	Melanoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation blocking phosphorylation signal	0.6667
p.S870F	ACH-000827	Skin Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation blocking phosphorylation signal	0.6667
p.S870F	WM793B	skin	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation blocking phosphorylation signal	0.6667
p.R865K	TCGA-D3-A8GQ	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.6126
p.S614T	DO228564	MALY	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.6005
p.V863I	TCGA-AG-A02N	READ	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	TCGA-AP-A1DV	UCEC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	TCGA-DD-AAD8	LIHC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	DO52226	LIHC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	DO37146	READ	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	DO43186	UCEC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965

Showing 1 to 20 of 79 entries

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Kaplan plot for EPB41L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L1

UniProt ID: Q9H4G0

Entrez ID: 2036

Protein name: Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L1 in