DegronMD - Q9H4G0(EPB41L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S607G	TCGA-64-5781	LUAD	TCGA	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.S607G	DO23740	LUAD	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.E872D	TCGA-A5-A1OF	UCEC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1667
p.T609M	TCGA-A6-2681	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.3056
p.T609M	DO9788	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.3056
p.T799N	TCGA-AB-2808	LAML	TCGA	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.6667
p.V863I	TCGA-AG-A02N	READ	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	TCGA-AP-A1DV	UCEC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	TCGA-DD-AAD8	LIHC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	DO52226	LIHC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	DO37146	READ	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	DO43186	UCEC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	SIDM01588	Endometrial Carcinoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	ACH-000705	Lung Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	ACH-000993	Endometrial/Uterine Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	ACH-001113	Lung Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	ACH-002156	Lung Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.V863I	LC-1-sq	lung	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.G797S	TCGA-AZ-4615	COAD	TCGA	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.G797S	TCGA-BF-AAP2	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.S746F	TCGA-BF-AAOX	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation altering degron motif	0.6871
p.S607R	TCGA-BR-4267	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.S607R	DO38316	STAD	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.S782F	TCGA-BS-A0UV	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.5278
p.S782F	DO42793	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.5278
p.T613A	TCGA-BT-A20J	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7139
p.T613A	DO457	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7139
p.V858L	TCGA-CV-A45W	HNSC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.2778
p.V858L	DO52060	HNSC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.2778
p.G732V	TCGA-D3-A2J6	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.0833
p.S753L	TCGA-D3-A3MV	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.1944
p.S753L	DO37727	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.1944
p.R865K	TCGA-D3-A8GQ	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.6126
p.S606C	TCGA-DK-A3IN	BLCA	TCGA	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.S606C	DO455	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.R781S	TCGA-EE-A29Q	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.P854S	TCGA-FW-A3R5	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1667
p.D855N	TCGA-WE-A8ZT	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1944
p.D855N	DO51290	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1944
p.M756I	DO225392	BRCA	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.1111
p.G796S	DO7977	COAD	ICGC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.75
p.G796S	DO219466	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation blocking phosphorylation signal	0.75
p.T798N	DO21487	LAML	ICGC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.V861F	DO228918	LICA	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.7068
p.E756D	DO229035	LICA	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.1111
p.V736A	DO23300	LINC	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.1944
p.S614T	DO228564	MALY	ICGC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.6005
p.P853S	DO37406	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1389
p.G731V	DO37901	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.0556
p.S745F	DO223907	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation altering degron motif	0.7982
p.R864K	DO51246	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.7237
p.P869A	DO229259	THCA	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.25
p.E871D	DO42568	UCEC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1944
p.E757G	SIDM02033	Colorectal Carcinoma	GDSC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.0833
p.K876R	SIDM00484	Thyroid Gland Carcinoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation substituting flanking lysine	0.1667
p.K876R	ACH-001321	Thyroid Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation substituting flanking lysine	0.1667
p.K876R	TT	thyroid	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation substituting flanking lysine	0.1667
p.S870F	SIDM00973	Melanoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation blocking phosphorylation signal	0.6667
p.S870F	ACH-000827	Skin Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation blocking phosphorylation signal	0.6667
p.S870F	WM793B	skin	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation blocking phosphorylation signal	0.6667
p.G788R	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.G788R	ACH-002393	Lymphoma	CCLE	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.G788R	CRO-AP3	NS	COSMIC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.25
p.R874T	SIDM00397	Acute Myeloid Leukemia	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1111
p.R874T	ACH-000195	Leukemia	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1111
p.R874T	Set2	haematopoietic and lymphoid tissue	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1111
p.I752V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.2222
p.I752V	ACH-000553	Lung Cancer	CCLE	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.2222
p.R781H	ACH-001664	Gastric Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.S869F	WM793B	skin	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.25
p.R873T	Set2	haematopoietic and lymphoid tissue	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.1389
p.V754I	LC-1-sq	lung	COSMIC	IATTPSIT	DEG_SCF_FBW7_1	741:748	Mutation rewiring degron network	0.1667
p.V621M	TOV-21G	ovary	COSMIC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.1389
p.V862I	LC-1-sq	lung	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation altering degron motif	0.5965
p.G608R	CRO-AP3	NS	COSMIC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2778
p.K875R	TT	thyroid	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	860:866	Mutation rewiring degron network	0.0833
p.G787R	CRO-AP3	NS	COSMIC	VLTST	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2222
p.A609T	DU-145	prostate	COSMIC	VSSTS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L1

UniProt ID: Q9H4G0

Entrez ID: 2036

Protein name: Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L1 in