DegronMD

Uniprot ID: Q9H4G0

Source protein: Band 4.1-like protein 1

Source gene: EPB41L1

Class: LIG_APCC_ABBAyCdc20_2

Location: 860:866

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.986

ASA_SCORE: 80.2571

COIL: 0.2451

CONS_SCORE: 0.6453

DSS_SCORE: 0.5537

HELIX: 0.0084

FCONS_SCORE: 1.2653

RIG_SCORE: 0.7734

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E872D	TCGA-A5-A1OF	UCEC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V863I	TCGA-AG-A02N	READ	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	TCGA-AP-A1DV	UCEC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	TCGA-DD-AAD8	LIHC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	DO52226	LIHC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	DO37146	READ	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	DO43186	UCEC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	SIDM01588	Endometrial Carcinoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	ACH-000705	Lung Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	ACH-000993	Endometrial/Uterine Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	ACH-001113	Lung Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	ACH-002156	Lung Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V863I	LC-1-sq	lung	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V858L	TCGA-CV-A45W	HNSC	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V858L	DO52060	HNSC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R865K	TCGA-D3-A8GQ	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.6126
p.P854S	TCGA-FW-A3R5	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D855N	TCGA-WE-A8ZT	SKCM	TCGA	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D855N	DO51290	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V861F	DO228918	LICA	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.7068
p.P853S	DO37406	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R864K	DO51246	SKCM	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.7237
p.P869A	DO229259	THCA	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.E871D	DO42568	UCEC	ICGC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K876R	SIDM00484	Thyroid Gland Carcinoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K876R	ACH-001321	Thyroid Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K876R	TT	thyroid	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S870F	SIDM00973	Melanoma	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S870F	ACH-000827	Skin Cancer	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S870F	WM793B	skin	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.6667
p.R874T	SIDM00397	Acute Myeloid Leukemia	GDSC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R874T	ACH-000195	Leukemia	CCLE	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R874T	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S869F	WM793B	skin	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.R873T	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V862I	LC-1-sq	lung	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.5965
p.K875R	TT	thyroid	COSMIC	KAVVYRE	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KAVVYRE

Degron related mutations and impact score

Drug responses associated with EPB41L1 mutations

All proteins holding degron of KAVVYRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4G0	Band 4.1-like protein 1	LIG_APCC_ABBAyCdc20_2	860:866	KAVVYRE	APC,CDC20,FZR1	0.986	More...