DegronMD

Uniprot ID: Q9H4G0

Source protein: Band 4.1-like protein 1

Source gene: EPB41L1

Class: DEG_SCF_FBW7_1

Location: 741:748

E3 ligase: FBXW7

DEGRON score: 0.9827

ASA_SCORE: 78.4

COIL: 0.7591

CONS_SCORE: 0.5679

DSS_SCORE: 0.4751

HELIX: 0.0261

FCONS_SCORE: 0.9871

RIG_SCORE: 0.7741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S746F	TCGA-BF-AAOX	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	0.6871
p.G732V	TCGA-D3-A2J6	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	0.0833
p.S753L	TCGA-D3-A3MV	SKCM	TCGA	IATTPSIT	DEG_SCF_FBW7_1	0.1944
p.S753L	DO37727	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	0.1944
p.M756I	DO225392	BRCA	ICGC	IATTPSIT	DEG_SCF_FBW7_1	0.1111
p.E756D	DO229035	LICA	ICGC	IATTPSIT	DEG_SCF_FBW7_1	0.1111
p.V736A	DO23300	LINC	ICGC	IATTPSIT	DEG_SCF_FBW7_1	0.1944
p.G731V	DO37901	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	0.0556
p.S745F	DO223907	SKCM	ICGC	IATTPSIT	DEG_SCF_FBW7_1	0.7982
p.E757G	SIDM02033	Colorectal Carcinoma	GDSC	IATTPSIT	DEG_SCF_FBW7_1	0.0833
p.I752V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	IATTPSIT	DEG_SCF_FBW7_1	0.2222
p.I752V	ACH-000553	Lung Cancer	CCLE	IATTPSIT	DEG_SCF_FBW7_1	0.2222
p.V754I	LC-1-sq	lung	COSMIC	IATTPSIT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4G0	Band 4.1-like protein 1	DEG_SCF_FBW7_1	741:748	IATTPSIT	FBXW7	0.9827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons