DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4708:4712

E3 ligase: SPOP

DEGRON score: 0.9684

ASA_SCORE: 100.58

COIL: 0.9304

CONS_SCORE: 0.2879

DSS_SCORE: 0.6109

HELIX: 0.0178

FCONS_SCORE: 1.0724

RIG_SCORE: 0.7412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4709P	DO229010	COCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T4709P	DO229013	COCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T4709P	DO229016	COCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T4709P	DO229003	COCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T4709P	DO229005	COCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T4709P	DO229346	LAML	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T4715M	DO231140	LAML	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.T4715M	DO229047	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.S4711T	ACH-000961	Endometrial/Uterine Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons