DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4310:4314

E3 ligase: SPOP

DEGRON score: 0.945

ASA_SCORE: 97.94

COIL: 0.8988

CONS_SCORE: 0.3066

DSS_SCORE: 0.5373

HELIX: 0.03

FCONS_SCORE: 1.037

RIG_SCORE: 0.748

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4313G	TCGA-23-2084	OV	TCGA	VLTST	DEG_SPOP_SBC_1	0.6993
p.P4309A	TCGA-37-A5EL	LUSC	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.T4321N	TCGA-44-2668	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.S4318Y	TCGA-91-6848	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.6667
p.T4312A	TCGA-A5-A0GP	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.7139
p.S4318F	TCGA-EE-A29E	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.6667
p.R4303K	TCGA-EE-A3AG	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.R4303K	TCGA-GN-A4U8	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.R4303K	TCGA-YG-AA3N	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.A4315T	TCGA-EE-A3JD	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.T4307A	TCGA-FD-A3N6	BLCA	TCGA	VLTST	DEG_SPOP_SBC_1	0.6944
p.T4307A	SIDM00158	Glioblastoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.6944
p.T4310A	DO575	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7139
p.T4307N	DO224709	BRCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.6944
p.A4308V	DO224709	BRCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.2778
p.S4316I	DO52707	CLLE	ICGC	VLTST	DEG_SPOP_SBC_1	0.7222
p.S4321Y	DO23846	LUAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.1389
p.P4312A	DO223718	LUSC	ICGC	VLTST	DEG_SPOP_SBC_1	0.7503
p.S4316G	DO30310	OV	ICGC	VLTST	DEG_SPOP_SBC_1	0.7222
p.S4321F	DO37831	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.1389
p.R4306K	DO37471	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222
p.R4306K	DO47320	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222
p.R4306K	DO51298	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222
p.A4318T	DO50299	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4302F	DO38727	STAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.T4315A	DO41109	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.3056
p.R4303M	SIDM00120	Prostate Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1389
p.R4303M	ACH-000979	Prostate Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.1389
p.R4303M	DU-145	prostate	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1389
p.S4322N	SIDM00607	Glioblastoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1111
p.S4322N	KNS-42	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1111
p.T4312R	SIDM00988	Kidney Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.7876
p.T4312R	BFTC-909	kidney	COSMIC	VLTST	DEG_SPOP_SBC_1	0.7876
p.A4305V	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	NCI-H1755	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	AU565	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	D-423MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	HCC202	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	HPAC	pancreas	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	SK-MEL-24	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	NCI-H2444	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	T47D	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	U-118-MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	U-87-MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	NCI-H1573	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	BICR78	upper_aerodigestive_tract	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	H290	pleura	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	Hs939-T	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A4305V	RPMI-2650	upper_aerodigestive_tract	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944
p.T4304N	H290	pleura	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	T47D	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	SK-MEL-24	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	D-423MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	U-87-MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	NCI-H2444	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	AU565	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	RPMI-2650	upper_aerodigestive_tract	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	HCC202	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	Hs939-T	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	U-118-MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	HPAC	pancreas	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.T4304N	NCI-H1573	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1667
p.K4317T	U-118-MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3611
p.K4317T	HCC202	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3611
p.K4317T	TOV-21G	ovary	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3611
p.K4317T	BICR78	upper_aerodigestive_tract	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3611
p.K4317T	HCT-15	large_intestine	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3611
p.K4317T	GCT	soft_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3611
p.S4318P	HCC202	breast	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4318P	TOV-21G	ovary	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4318P	M14	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4318P	U-118-MG	central_nervous_system	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4318P	BICR78	upper_aerodigestive_tract	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4318P	HCT-15	large_intestine	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667
p.S4318P	RPMI-2650	upper_aerodigestive_tract	COSMIC	VLTST	DEG_SPOP_SBC_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLTST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VLTST