DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3053:3057

E3 ligase: SPOP

DEGRON score: 0.9787

ASA_SCORE: 97.3

COIL: 0.8376

CONS_SCORE: 0.2775

DSS_SCORE: 0.4987

HELIX: 0.0224

FCONS_SCORE: 1.0147

RIG_SCORE: 0.7604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3049P	TCGA-AP-A056	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.2222
p.S3061Y	TCGA-DD-A4NG	LIHC	TCGA	VLTST	DEG_SPOP_SBC_1	0.6667
p.R3046M	TCGA-EB-A6QY	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.P3052S	TCGA-Z2-A8RT	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.K3063T	DO229062	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	0.1667
p.S3064Y	DO44885	LIHC	ICGC	VLTST	DEG_SPOP_SBC_1	0.1389
p.V3056A	DO52652	MALY	ICGC	VLTST	DEG_SPOP_SBC_1	0.6936
p.R3049M	DO48702	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222
p.P3055S	DO51301	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.6752
p.T3052P	DO43971	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.3056
p.A3048T	SIDM01265	Plasma Cell Myeloma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00773	Non-Cancerous	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00969	Ovarian Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00393	Gastric Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00694	Other Solid Cancers	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM00774	Breast Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.A3048T	SIDM01664	Prostate Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.1944
p.L3051F	SIDM01104	Melanoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.2778
p.L3051F	ACH-000640	Skin Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.2778
p.L3051F	SK-MEL-31	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.2778
p.A3058T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VLTST	DEG_SPOP_SBC_1	0.3056
p.A3058T	SIDM00500	Colorectal Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.3056
p.A3058T	ACH-000937	Leukemia	CCLE	VLTST	DEG_SPOP_SBC_1	0.3056
p.A3058T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLTST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VLTST