DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3024:3028

E3 ligase: SPOP

DEGRON score: 0.9812

ASA_SCORE: 96.52

COIL: 0.919

CONS_SCORE: 0.3538

DSS_SCORE: 0.672

HELIX: 0.0218

FCONS_SCORE: 1.1766

RIG_SCORE: 0.6867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3035I	TCGA-44-7671	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.P3021S	TCGA-58-8386	LUSC	TCGA	VLTST	DEG_SPOP_SBC_1	0.25
p.S3027N	TCGA-A6-6781	COAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.7069
p.S3027N	SIDM00660	Colorectal Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.7069
p.S3027N	ACH-000985	Colon/Colorectal Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.7069
p.S3027N	LS-411N	large_intestine	COSMIC	VLTST	DEG_SPOP_SBC_1	0.7069
p.P3016L	TCGA-AX-A1C9	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.1111
p.P3016L	TCGA-AZ-6599	COAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.1111
p.L3025P	TCGA-BG-A221	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.6471
p.P3020L	TCGA-DX-A1KX	SARC	TCGA	VLTST	DEG_SPOP_SBC_1	0.2222
p.P3019L	DO10606	COAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.1944
p.P3019L	DO43098	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.1944
p.S3030N	DO8447	COAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.7222
p.T3038I	DO25252	LUAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.1667
p.P3024S	DO45537	LUSC	ICGC	VLTST	DEG_SPOP_SBC_1	0.6752
p.P3023L	DO219946	SARC	ICGC	VLTST	DEG_SPOP_SBC_1	0.3056
p.L3028P	DO42384	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.7582
p.A3029T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VLTST	DEG_SPOP_SBC_1	0.3056
p.A3029T	ACH-001127	Leukemia	CCLE	VLTST	DEG_SPOP_SBC_1	0.3056
p.A3029T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3056
p.T3028P	SIDM01617	Endometrial Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.7031
p.T3033P	ACH-000024	Myeloma	CCLE	VLTST	DEG_SPOP_SBC_1	0.1944
p.T3033P	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons