DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3195:3199

E3 ligase: SPOP

DEGRON score: 0.8767

ASA_SCORE: 98.66

COIL: 0.8852

CONS_SCORE: 0.2178

DSS_SCORE: 0.4477

HELIX: 0.0296

FCONS_SCORE: 0.8268

RIG_SCORE: 0.7908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3200T	TCGA-A5-A0GA	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.V3205F	TCGA-AP-A0LM	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.1667
p.T3199M	TCGA-B5-A0JV	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.7423
p.S3207N	TCGA-DF-A2KU	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.5556
p.S3187F	DO219046	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.V3208F	DO43306	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.0833
p.A3203T	DO43763	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222
p.T3202M	DO43979	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.S3207C	SIDM00697	Small Cell Lung Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.5556
p.S3207C	ACH-000830	Lung Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.5556
p.S3207C	NCI-H1436	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.5556
p.G3191D	SIDM00781	Colorectal Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.2222
p.G3191D	SIDM00780	Colorectal Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.2222
p.G3191D	ACH-000967	Colon/Colorectal Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.2222
p.S3198N	SIDM00151	Ovarian Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.7069
p.S3198N	IGROV-1	ovary	COSMIC	VLTST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons