DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4737:4741

E3 ligase: SPOP

DEGRON score: 0.9525

ASA_SCORE: 98.62

COIL: 0.9238

CONS_SCORE: 0.2416

DSS_SCORE: 0.4818

HELIX: 0.0242

FCONS_SCORE: 0.9512

RIG_SCORE: 0.7657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4742T	TCGA-06-5416	GBM	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.A4747D	TCGA-78-8640	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	0.1667
p.A4747V	TCGA-A5-A1OF	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.1667
p.A4742S	TCGA-AX-A1CE	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.R4730M	TCGA-FS-A1ZG	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.S4729F	DO51607	CESC	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.A4745T	DO10880	GBM	ICGC	VLTST	DEG_SPOP_SBC_1	0.6667
p.T4737I	DO231700	LINC	ICGC	VLTST	DEG_SPOP_SBC_1	0.7078
p.A4750D	DO45340	LUAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.0833
p.S4729Y	DO45322	LUAD	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.R4733M	DO37523	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.2222
p.A4745S	DO42280	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.6667
p.A4750V	DO42568	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons