DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9265:9269

E3 ligase: SPOP

DEGRON score: 0.9834

ASA_SCORE: 86.78

COIL: 0.8254

CONS_SCORE: 0

DSS_SCORE: 0.459

HELIX: 0.015

FCONS_SCORE: 0

RIG_SCORE: 0.7711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V9265I	TCGA-12-0670	GBM	TCGA	VLTST	DEG_SPOP_SBC_1	0.7076
p.V9265I	TCGA-W3-A828	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.7076
p.V9265I	DO12226	GBM	ICGC	VLTST	DEG_SPOP_SBC_1	0.7076
p.V9265I	DO51273	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.7076
p.D9262Y	TCGA-B5-A1MR	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.25
p.D9262Y	DO41758	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.T9263R	TCGA-CR-7402	HNSC	TCGA	VLTST	DEG_SPOP_SBC_1	0.2778
p.T9263R	DO15727	HNSC	ICGC	VLTST	DEG_SPOP_SBC_1	0.2778
p.T9263I	TCGA-E6-A1LX	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.2778
p.T9263I	DO41020	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.2778
p.V9265A	TCGA-FI-A2D5	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.5825
p.V9265A	DO41331	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.5825
p.L9266I	DO222762	COCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.6063
p.S9276I	DO44868	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	0.1389
p.D9262G	DO23188	LINC	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.R9277K	DO220889	MELA	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.R9277M	DO220907	MELA	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.G9255S	SIDM01729	Endometrial Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.0556
p.G9255S	ACH-000909	Endometrial/Uterine Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons