DegronMD - Q5T8D3(ACBD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N174I	TCGA-17-Z017	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.25
p.V178F	TCGA-44-7661	LUAD	TCGA	VLTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.7068
p.E190K	TCGA-AX-A1CE	UCEC	TCGA	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation substituting flanking lysine	0.3056
p.E190K	TCGA-AX-A1CE	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.1944
p.E190K	TCGA-AX-A2HC	UCEC	TCGA	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation substituting flanking lysine	0.3056
p.E190K	TCGA-AX-A2HC	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	177:181	Mutation substituting flanking lysine	0.1944
p.K210N	TCGA-E6-A1LX	UCEC	TCGA	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation substituting flanking lysine	0.1667
p.E198K	TCGA-GU-A42Q	BLCA	TCGA	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.7022
p.E192K	DO48414	BLCA	ICGC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation rewiring degron network	0.25
p.E207K	DO485	BLCA	ICGC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation rewiring degron network	0.1389
p.P182T	DO225346	BRCA	ICGC	VLTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.3056
p.D195Y	DO50407	ESAD	ICGC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.7325
p.H291D	DO233287	GACA	ICGC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1944
p.V292F	DO233858	GACA	ICGC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1667
p.S180Y	DO229036	LICA	ICGC	VLTST	DEG_SPOP_SBC_1	177:181	Mutation altering degron motif	0.712
p.N272K	DO229037	LICA	ICGC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.0833
p.Q275K	DO229009	LICA	ICGC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1667
p.V187F	DO23602	LUAD	ICGC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation rewiring degron network	0.1111
p.V187F	DO23602	LUAD	ICGC	VLTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1667
p.E199K	DO42280	UCEC	ICGC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.591
p.E199K	DO41572	UCEC	ICGC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.591
p.E199K	SIDM00942	Oral Cavity Carcinoma	GDSC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.591
p.E199K	SIDM00294	Small Cell Lung Carcinoma	GDSC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.591
p.E199K	SIDM00166	Other Solid Cancers	GDSC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation altering degron motif	0.591
p.N288S	SIDM00499	Prostate Carcinoma	GDSC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.2778
p.N288S	22RV1	prostate	COSMIC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.2778
p.E202G	SIDM00909	Melanoma	GDSC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation rewiring degron network	0.2778
p.E202G	COLO-829	skin	COSMIC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation rewiring degron network	0.2778
p.E193G	ACH-000644	Skin Cancer	CCLE	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation blocking phosphorylation signal	0.7222
p.E193G	COLO-829	skin	COSMIC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation blocking phosphorylation signal	0.7222
p.N279S	ACH-000956	Prostate Cancer	CCLE	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation blocking phosphorylation signal	0.7222
p.N279S	22RV1	prostate	COSMIC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation blocking phosphorylation signal	0.7222
p.G271R	NCI-H2135	lung	COSMIC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.0556
p.G271R	NCI-H1581	lung	COSMIC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.0556
p.E284G	AGS	stomach	COSMIC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation altering degron motif	0.7199
p.E191G	COLO-829	skin	COSMIC	DSGAES	DEG_SCF_TRCP1_1	195:200	Mutation rewiring degron network	0.2222
p.E191G	COLO-829	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.0556
p.D183N	LOXIMVI	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.2778
p.N170S	22RV1	prostate	COSMIC	VLTST	DEG_SPOP_SBC_1	177:181	Mutation rewiring degron network	0.1389
p.N277S	22RV1	prostate	COSMIC	VCIHQD	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.2222

Kaplan plot for ACBD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACBD5

UniProt ID: Q5T8D3

Entrez ID: 91452

Protein name: Acyl-CoA-binding domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACBD5 in