DegronMD

Uniprot ID: Q5T8D3

Source protein: Acyl-CoA-binding domain-containing protein 5

Source gene: ACBD5

Class: LIG_APCC_ABBA_1

Location: 281:286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8966

ASA_SCORE: 67.4333

COIL: 0.6538

CONS_SCORE: 0.4476

DSS_SCORE: 0.4779

HELIX: 0.1205

FCONS_SCORE: 1.0014

RIG_SCORE: 0.7992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H291D	DO233287	GACA	ICGC	VCIHQD	LIG_APCC_ABBA_1	0.1944
p.V292F	DO233858	GACA	ICGC	VCIHQD	LIG_APCC_ABBA_1	0.1667
p.N272K	DO229037	LICA	ICGC	VCIHQD	LIG_APCC_ABBA_1	0.0833
p.Q275K	DO229009	LICA	ICGC	VCIHQD	LIG_APCC_ABBA_1	0.1667
p.N288S	SIDM00499	Prostate Carcinoma	GDSC	VCIHQD	LIG_APCC_ABBA_1	0.2778
p.N288S	22RV1	prostate	COSMIC	VCIHQD	LIG_APCC_ABBA_1	0.2778
p.N279S	ACH-000956	Prostate Cancer	CCLE	VCIHQD	LIG_APCC_ABBA_1	0.7222
p.N279S	22RV1	prostate	COSMIC	VCIHQD	LIG_APCC_ABBA_1	0.7222
p.G271R	NCI-H2135	lung	COSMIC	VCIHQD	LIG_APCC_ABBA_1	0.0556
p.G271R	NCI-H1581	lung	COSMIC	VCIHQD	LIG_APCC_ABBA_1	0.0556
p.E284G	AGS	stomach	COSMIC	VCIHQD	LIG_APCC_ABBA_1	0.7199
p.N277S	22RV1	prostate	COSMIC	VCIHQD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	LIG_APCC_ABBA_1	281:286	VCIHQD	APC,CDC20,FZR1	0.8966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons