DegronMD

Uniprot ID: Q5T8D3

Source protein: Acyl-CoA-binding domain-containing protein 5

Source gene: ACBD5

Class: DEG_SCF_TRCP1_1

Location: 195:200

E3 ligase: BTRC

DEGRON score: 0.9962

ASA_SCORE: 82.9167

COIL: 0.8407

CONS_SCORE: 0.5387

DSS_SCORE: 0.7286

HELIX: 0.1438

FCONS_SCORE: 1.0937

RIG_SCORE: 0.5565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E190K	TCGA-AX-A1CE	UCEC	TCGA	DSGAES	DEG_SCF_TRCP1_1	0.3056
p.E190K	TCGA-AX-A2HC	UCEC	TCGA	DSGAES	DEG_SCF_TRCP1_1	0.3056
p.K210N	TCGA-E6-A1LX	UCEC	TCGA	DSGAES	DEG_SCF_TRCP1_1	0.1667
p.E198K	TCGA-GU-A42Q	BLCA	TCGA	DSGAES	DEG_SCF_TRCP1_1	0.7022
p.E192K	DO48414	BLCA	ICGC	DSGAES	DEG_SCF_TRCP1_1	0.25
p.E207K	DO485	BLCA	ICGC	DSGAES	DEG_SCF_TRCP1_1	0.1389
p.D195Y	DO50407	ESAD	ICGC	DSGAES	DEG_SCF_TRCP1_1	0.7325
p.V187F	DO23602	LUAD	ICGC	DSGAES	DEG_SCF_TRCP1_1	0.1111
p.E199K	DO42280	UCEC	ICGC	DSGAES	DEG_SCF_TRCP1_1	0.591
p.E199K	DO41572	UCEC	ICGC	DSGAES	DEG_SCF_TRCP1_1	0.591
p.E199K	SIDM00942	Oral Cavity Carcinoma	GDSC	DSGAES	DEG_SCF_TRCP1_1	0.591
p.E199K	SIDM00294	Small Cell Lung Carcinoma	GDSC	DSGAES	DEG_SCF_TRCP1_1	0.591
p.E199K	SIDM00166	Other Solid Cancers	GDSC	DSGAES	DEG_SCF_TRCP1_1	0.591
p.E202G	SIDM00909	Melanoma	GDSC	DSGAES	DEG_SCF_TRCP1_1	0.2778
p.E202G	COLO-829	skin	COSMIC	DSGAES	DEG_SCF_TRCP1_1	0.2778
p.E193G	ACH-000644	Skin Cancer	CCLE	DSGAES	DEG_SCF_TRCP1_1	0.7222
p.E193G	COLO-829	skin	COSMIC	DSGAES	DEG_SCF_TRCP1_1	0.7222
p.E191G	COLO-829	skin	COSMIC	DSGAES	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SCF_TRCP1_1	195:200	DSGAES	BTRC	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons