DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 7808:7812

E3 ligase: SPOP

DEGRON score: 0.7921

ASA_SCORE: 82.76

COIL: 0.7574

CONS_SCORE: 0

DSS_SCORE: 0.4713

HELIX: 0.0126

FCONS_SCORE: 0

RIG_SCORE: 0.7742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P7813L	TCGA-43-6770	LUSC	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.P7813L	DO27644	LUSC	ICGC	VLTST	DEG_SPOP_SBC_1	0.3056
p.L7809V	TCGA-85-8481	LUSC	TCGA	VLTST	DEG_SPOP_SBC_1	0.5654
p.L7809V	DO45465	LUSC	ICGC	VLTST	DEG_SPOP_SBC_1	0.5654
p.R7820M	TCGA-A5-A1OF	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.1111
p.R7820M	DO42568	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.1111
p.S7807R	TCGA-EO-A22R	UCEC	TCGA	VLTST	DEG_SPOP_SBC_1	0.3056
p.S7807R	DO42713	UCEC	ICGC	VLTST	DEG_SPOP_SBC_1	0.3056
p.D7805E	TCGA-S5-A6DX	BLCA	TCGA	VLTST	DEG_SPOP_SBC_1	0.25
p.D7805E	DO51903	BLCA	ICGC	VLTST	DEG_SPOP_SBC_1	0.25
p.S7801F	TCGA-W3-AA1Q	SKCM	TCGA	VLTST	DEG_SPOP_SBC_1	0.1389
p.S7801F	DO219487	SKCM	ICGC	VLTST	DEG_SPOP_SBC_1	0.1389
p.T7812P	DO233646	GACA	ICGC	VLTST	DEG_SPOP_SBC_1	0.7031
p.S7807N	SIDM00710	Small Cell Lung Carcinoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.3056
p.S7807N	ACH-000394	Lung Cancer	CCLE	VLTST	DEG_SPOP_SBC_1	0.3056
p.S7807N	NCI-H2081	lung	COSMIC	VLTST	DEG_SPOP_SBC_1	0.3056
p.V7808F	SIDM00975	Melanoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.7068
p.V7808F	WM278	skin	COSMIC	VLTST	DEG_SPOP_SBC_1	0.7068
p.A7814V	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLTST	DEG_SPOP_SBC_1	0.2778
p.A7814V	ACH-001498	Lymphoma	CCLE	VLTST	DEG_SPOP_SBC_1	0.2778
p.A7814V	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	VLTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	524:528	VLTST	SPOP	0.9878	More...
Q5T1R4	Transcription factor HIVEP3	DEG_SPOP_SBC_1	1471:1475	VLTST	SPOP	0.9481	More...
Q5T8D3	Acyl-CoA-binding domain-containing protein 5	DEG_SPOP_SBC_1	177:181	VLTST	SPOP	0.998	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7808:7812	VLTST	SPOP	0.7921	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9265:9269	VLTST	SPOP	0.9834	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	791:795	VLTST	SPOP	0.6823	More...
Q9H8V3	Protein ECT2	DEG_SPOP_SBC_1	6:10	VLTST	SPOP	0.9236	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3024:3028	VLTST	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3053:3057	VLTST	SPOP	0.9787	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3195:3199	VLTST	SPOP	0.8767	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4310:4314	VLTST	SPOP	0.945	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4708:4712	VLTST	SPOP	0.9684	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4737:4741	VLTST	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons