DegronMD

Uniprot ID: P54132

Source protein: Bloom syndrome protein

Source gene: BLM

Class: DEG_SCF_FBW7_1

Location: 170:175

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 76.6833

COIL: 0.873

CONS_SCORE: 0.2405

DSS_SCORE: 0.4673

HELIX: 0.0838

FCONS_SCORE: 1.1101

RIG_SCORE: 0.694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q184L	TCGA-60-2711	LUSC	TCGA	VTPPQS	DEG_SCF_FBW7_1	0.0833
p.Q184L	DO26987	LUSC	ICGC	VTPPQS	DEG_SCF_FBW7_1	0.0833
p.S175I	TCGA-63-A5MB	LUSC	TCGA	VTPPQS	DEG_SCF_FBW7_1	0.8453
p.S175I	DO52018	LUSC	ICGC	VTPPQS	DEG_SCF_FBW7_1	0.8453
p.Q184E	TCGA-AC-A23H	BRCA	TCGA	VTPPQS	DEG_SCF_FBW7_1	0.0833
p.Q184E	DO2401	BRCA	ICGC	VTPPQS	DEG_SCF_FBW7_1	0.0833
p.R179I	TCGA-DD-AADO	LIHC	TCGA	VTPPQS	DEG_SCF_FBW7_1	0.2222
p.R179I	DO52241	LIHC	ICGC	VTPPQS	DEG_SCF_FBW7_1	0.2222
p.D161Y	DO229018	LICA	ICGC	VTPPQS	DEG_SCF_FBW7_1	0.0833
p.Q184H	DO229015	LICA	ICGC	VTPPQS	DEG_SCF_FBW7_1	0.0833
p.T162I	SIDM01617	Endometrial Carcinoma	GDSC	VTPPQS	DEG_SCF_FBW7_1	0.1111
p.T162I	ACH-000994	Endometrial/Uterine Cancer	CCLE	VTPPQS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SCF_FBW7_1	170:175	VTPPQS	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons