DegronMD

Uniprot ID: P54132

Source protein: Bloom syndrome protein

Source gene: BLM

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.5966

ASA_SCORE: 70.46

COIL: 0.5804

CONS_SCORE: 0.1979

DSS_SCORE: 0.5516

HELIX: 0.3812

FCONS_SCORE: 0.946

RIG_SCORE: 0.7273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D340Y	TCGA-AP-A0LM	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2778
p.D340Y	DO229257	THCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2778
p.D340Y	DO43306	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2778
p.V334I	TCGA-AX-A0J1	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.7076
p.V334I	DO41199	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7076
p.L335F	TCGA-FR-A726	SKCM	TCGA	VLSTS	DEG_SPOP_SBC_1	0.587
p.L335F	DO48665	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	0.587
p.M348I	TCGA-UC-A7PG	CESC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348I	DO51615	CESC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348I	DO229005	COCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348I	SIDM00588	Oral Cavity Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348I	SIDM01447	Glioblastoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348I	HSC-4	upper_aerodigestive_tract	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348V	TCGA-Y8-A894	KIRP	TCGA	VLSTS	DEG_SPOP_SBC_1	0.0556
p.M348V	DO49798	KIRP	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.S328C	TCGA-ZF-AA54	BLCA	TCGA	VLSTS	DEG_SPOP_SBC_1	0.6111
p.S328C	DO219098	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.6111
p.E346K	DO223035	ESCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.S336I	DO229036	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7341
p.V334F	DO229045	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7068
p.D329H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.D329H	ACH-000995	Leukemia	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1944
p.D329H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.K347N	SIDM00118	Colorectal Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.K347N	ACH-001081	Colon/Colorectal Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.1944
p.K347N	HCC2998	large_intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSTS

Degron related mutations and impact score

Drug responses associated with BLM mutations

All proteins holding degron of VLSTS